A meta-analysis of the prognostic significance of cardiopulmonary exercise testing in patients with heart failure

被引：105

作者：

Cahalin, Lawrence P. ^{[1
]}

Chase, Paul ^{[2
]}

Arena, Ross ^{[3
,4
]}

Myers, Jonathan ^{[5
]}

Bensimhon, Daniel ^{[2
]}

Peberdy, Mary Ann ^{[6
]}

Ashley, Euan ^{[7
]}

West, Erin ^{[12
]}

Forman, Daniel E. ^{[12
]}

Pinkstaff, Sherry ^{[11
]}

Lavie, Carl J. ^{[9
,10
]}

Guazzi, Marco ^{[8
]}

机构：

[1] Univ Miami, Leonard M Miller Sch Med, Dept Phys Therapy, Coral Gables, FL 33146 USA

[2] Lebauer Cardiovasc Res Fdn, Greensboro, NC USA

[3] Univ New Mexico, Dept Orthopaed, Phys Therapy Program, Albuquerque, NM 87131 USA

[4] Univ New Mexico, Dept Internal Med, Div Cardiol, Albuquerque, NM 87131 USA

[5] VA Palo Alto Healthcare Syst, Div Cardiol, Palo Alto, CA USA

[6] Virginia Commonwealth Univ, Dept Internal Med, Richmond, VA USA

[7] Stanford Univ, Palo Alto, CA 94304 USA

[8] Univ Milan, IRCCS Policlin San Donato, San Donato Milanese, Italy

[9] Louisiana State Univ Syst, Pennington Biomed Res Ctr, Baton Rouge, LA USA

[10] Univ Queensland, Sch Med, John Ochsner Heart & Vasc Inst, Dept Cardiovasc Dis,Ochsner Clin Sch, New Orleans, LA USA

[11] Univ N Florida, Brooks Coll Hlth, Phys Therapy Program, Jacksonville, FL USA

[12] Brigham & Womens Hosp, Div Cardiovasc Med, Boston, MA 02115 USA

来源：

HEART FAILURE REVIEWS | 2013年 / 18卷 / 01期

关键词：

Ventilation; Aerobic capacity; Expired gas; Exercise; Heart disease; LEFT-VENTRICULAR DYSFUNCTION; OXYGEN-CONSUMPTION; STATEMENT; RECOMMENDATIONS; PERFORMANCE; VENTILATION; SLOPE; ASSOCIATION; EFFICIENCY;

D O I：

10.1007/s10741-012-9332-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The objective of the study is to assess the role of cardiopulmonary exercise testing (CPX) variables, including peak oxygen consumption (VO2), which is the most recognized CPX variable, the minute ventilation/carbon dioxide production (VE/VCO2) slope, the oxygen uptake efficiency slope (OUES), and exercise oscillatory ventilation (EOV) in a current meta-analysis investigating the prognostic value of a broader list of CPX-derived variables for major adverse cardiovascular events in patients with HF. A search for relevant CPX articles was performed using standard meta-analysis methods. Of the initial 890 articles found, 30 met our inclusion criteria and were included in the final analysis. The total subject populations included were as follows: peak VO2 (7,319), VE/VCO2 slope (5,044), EOV (1,617), and OUES (584). Peak VO2, the VE/VCO2 slope and EOV were all highly significant prognostic markers (diagnostic odds ratios a parts per thousand yen 4.10). The OUES also demonstrated promise as a prognostic marker (diagnostic odds ratio = 8.08) but only in a limited number of studies (n = 2). No other independent variables (including age, ejection fraction, and beta-blockade) had a significant effect on the meta-analysis results for peak VO2 and the VE/VCO2 slope. CPX is an important component in the prognostic assessment of patients with HF. The results of this meta-analysis strongly confirm this and support a multivariate approach to the application of CPX in this patient population.

引用

页码：79 / 94

页数：16

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