A novel synthesis of benzo[c]phenanthridine skeleton and biological evaluation of isoquinoline derivatives

被引：0
|
作者：
Cho, WJ
Park, MJ
Imanishi, T
Chung, BH
机构：
[1] Chonnam Natl Univ, Coll Pharm, Buk Gu, Kwangju 500757, South Korea
[2] Osaka Univ, Fac Pharmaceut Sci, Suita, Osaka 5650871, Japan
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 1999年 / 47卷 / 06期
关键词：
benzo[c]phenanthridine; indenoisoquinoline; antitumor activity; radical cyclization;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Benzo[c]phenanthridine skeleton was synthesized from easily available starting N-methyl-o-toluamide 2 and o-methylbenzonitrile 5 in 7 steps. Radical cyclization of styrene 10 afforded 6,11-dimethyl-6,11-dihydro-5H-indeno[1,2-c] isoquinolin-5-one 13, Most 3-arylisoquinolines have displayed strong activities against human tumor cell lines. Especially, indenoisoquinolinone 13 exhibited excellent cytotoxicity (IC50 = 0,002 mu g/ml; HCT 15).
引用
收藏
页码：900 / 902
页数：3
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