A mild and expedient one-pot synthesis of substituted benzimidazoles in water using a phase-transfer catalyst

被引：18

作者：

Chakrabarty, Manas ^{[1
]}

Karmakar, Sulakshana ^{[1
]}

Mukherjee, Ratna ^{[1
]}

Arima, Shiho ^{[2
]}

Harigaya, Yoshihiro ^{[2
]}

机构：

[1] Bose Inst, Dept Chem, Kolkata 700009, India

[2] Kitasato Univ, Sch Pharmaceut Sci, Minato Ku, Tokyo 108, Japan

来源：

MONATSHEFTE FUR CHEMIE | 2009年 / 140卷 / 04期

关键词：

Benzimidazoles; Synthesis; N-alkyl/phenyl-o-phenylenediamines; Aryl aldehydes; Phase-transfer catalyst; ECO-FRIENDLY CATALYST; DIELS-ALDER REACTIONS; PROMOTED SYNTHESIS; 2-SUBSTITUTED BENZIMIDAZOLES; SELECTIVE SYNTHESIS; O-PHENYLENEDIAMINE; EFFICIENT; ACID; DERIVATIVES; ALDEHYDES;

D O I：

10.1007/s00706-008-0036-z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

1-Alkyl/phenyl-2-arylbenzimidazoles have been synthesized in very good to excellent yields by a one-pot condensation of N-alkyl/phenyl-o-phenylenediamines with aryl aldehydes in water at room temperature using cetyl-pyridinium bromide as a cheap and eco-friendly catalyst.

引用

页码：375 / 380

页数：6

共 57 条

[1] A parallel-group comparison of astemizole and loratadine for the treatment of perennial allergic rhinitis [J].