Transmission of hepatitis C virus: Self-limiting hepatitis or chronic hepatitis?

被引：13
作者：
Saito, Takafumi [1 ]
Ueno, Yoshiyuki [1 ]
机构：
[1] Yamagata Univ, Sch Med, Dept Gastroenterol, Yamagata 9909585, Japan
来源：
WORLD JOURNAL OF GASTROENTEROLOGY | 2013年 / 19卷 / 41期
关键词：
hepatitis C; spontaneous clearance; Interleukin; 28B; single nucleotide polymorphism; interferon-lambda; MOLECULAR EVOLUTIONARY ANALYSIS; GENOME-WIDE ASSOCIATION; INDUCED VIRAL CLEARANCE; NEEDLESTICK ACCIDENTS; RESOLVING HEPATITIS; GENETIC-VARIATION; INFECTION; IL28B; INTERFERON; THERAPY;
D O I：
10.3748/wjg.v19.i41.6957
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
It has been suggested that hepatitis C virus (HCV) is selectively transmitted to a new host as an infectious clone from multiple HCV variants (quasispecies) in the donor. Most individuals with HCV infection develop chronic hepatitis, but approximately 15%-40% of them clear the virus spontaneously and the hepatitis is resolved in a self-limiting manner in the acute phase of infection. This difference in the outcome of acute hepatitis C is attributable to both viral characteristics and genetic regulation of infection. In particular, the evolutionary dynamics of the infecting virus and host genetic polymorphisms pertaining mainly to the immune system, including polymorphisms in the region of the Interleukin 28B gene encoding interferon-lambda-3, are associated with susceptibility to HCV infection. (C) 2013 Baishideng Publishing Group Co., Limited. All rights reserved.
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收藏
页码：6957 / 6961
页数：5
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