Antihistaminic drug olopatadine downmodulates T cell chemotaxis toward CXCL10 by reducing CXCR3 expression, F-actin polymerization and calcium influx in patients with alopecia areata

被引：14
作者：
Ito, Taisuke [1 ]
Fujiyama, Toshiharu [1 ]
Hashizume, Hideo [2 ]
Tokura, Yoshiki [1 ]
机构：
[1] Hamamatsu Univ, Sch Med, Dept Dermatol, Higashi Ku, Hamamatsu, Shizuoka 4313192, Japan
[2] Shimada Municipal Hosp, Dermatol Sect, Shimada 4278502, Japan
来源：
JOURNAL OF DERMATOLOGICAL SCIENCE | 2013年 / 72卷 / 01期
关键词：
MODEL;
D O I：
10.1016/j.jdermsci.2013.04.029
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
引用
收藏
页码：68 / 71
页数：4
相关论文
共 10 条
  • [1] Medical Progress Alopecia Areata
    Gilhar, Amos
    Etzioni, Amos
    Paus, Ralf
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2012, 366 (16) : 1515 - 1525
  • [2] Fexofenadine hydrochloride enhances the efficacy of contact immunotherapy for extensive alopecia areata: Retrospective analysis of 121 cases
    Inui, Shigeki
    Nakajima, Takeshi
    Toda, Naoyuki
    Itami, Satoshi
    [J]. JOURNAL OF DERMATOLOGY, 2009, 36 (06) : 323 - 327
  • [3] CXCL10 produced from hair follicles induces Th1 and Tc1 cell infiltration in the acute phase of alopecia areata followed by sustained Tc1 accumulation in the chronic phase
    Ito, Taisuke
    Hashizume, Hideo
    Shimauchi, Takatoshi
    Funakoshi, Atsuko
    Ito, Natsuho
    Fukamizu, Hidekazu
    Takigawa, Masahiro
    Tokura, Yoshiki
    [J]. JOURNAL OF DERMATOLOGICAL SCIENCE, 2013, 69 (02) : 140 - 147
  • [4] Advances in the management of alopecia areata
    Ito, Taisuke
    [J]. JOURNAL OF DERMATOLOGY, 2012, 39 (01) : 11 - 17
  • [5] Hair follicle is a target of stress hormone and autoimmune reactions
    Ito, Taisuke
    [J]. JOURNAL OF DERMATOLOGICAL SCIENCE, 2010, 60 (02) : 67 - 73
  • [6] McElwee KJ, 1999, BRIT J DERMATOL, V140, P432
  • [7] Controlled delivery of T-box21 small interfering RNA ameliorates autoimmune alopecia (alopecia areata) in a C3H/HeJ mouse model
    Nakamura, Motonobu
    Jo, Jun-ichiro
    Tabata, Yasuhiko
    Ishikawa, Osamu
    [J]. AMERICAN JOURNAL OF PATHOLOGY, 2008, 172 (03) : 650 - 658
  • [8] Experimental evaluation of ebastine, a second-generation anti-histamine, as a supportive medication for alopecia areata
    Ohyama, Manabu
    Shimizu, Atsushi
    Tanaka, Kyoko
    Amagai, Masayuki
    [J]. JOURNAL OF DERMATOLOGICAL SCIENCE, 2010, 58 (02) : 154 - 157
  • [9] Antihistaminic drug olopatadine downmodulates CCL17/TARC production by keratinocytes and Langerhans cells
    Sugita, Kazunari
    Kobayashi, Miwa
    Mori, Tomoko
    Kabashima, Kenji
    Nakamura, Motonobu
    Tokura, Yoshiki
    [J]. JOURNAL OF DERMATOLOGY, 2009, 36 (12) : 654 - 657
  • [10] Epidermal chemokines and modulation by antihistamines, antibiotics and antifungals
    Tokura, Yoshiki
    Kobayashi, Miwa
    Kabashima, Kenji
    [J]. EXPERIMENTAL DERMATOLOGY, 2008, 17 (02) : 81 - 90
1