Assessment of local structural disorders of the bladder wall in partial bladder outlet obstruction using polarized light imaging

被引：25

作者：

Alali, Sanaz ^{[1
,2
]}

Aitken, Karen J. ^{[3
]}

Schroeder, Annette ^{[3
]}

Gribble, Adam ^{[1
,2
]}

Bagli, Darius J. ^{[3
]}

Vitkin, I. Alex ^{[1
,2
,4
]}

机构：

[1] Univ Toronto, Univ Hlth Network, Ontario Canc Inst, Div Biophys & Bioimaging, Toronto, ON M5G 2M9, Canada

[2] Dept Med Biophys, Toronto, ON M5G 2M9, Canada

[3] Univ Toronto, Sick Kids Hosp, Div Urol Dev & Stem Cell Biol, Toronto, ON M5G 1X8, Canada

[4] Univ Toronto, Dept Radiat Oncol, Toronto, ON M5G 2M9, Canada

来源：

BIOMEDICAL OPTICS EXPRESS | 2014年 / 5卷 / 02期

关键词：

SMOOTH-MUSCLE; URINARY-BLADDER; IN-VIVO; MATRIX; TISSUE; RAT; DECOMPOSITION; AUGMENTATION; SPECTROSCOPY; SCATTERING;

D O I：

10.1364/BOE.5.000621

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Partial bladder outlet obstruction causes prominent morphological changes in the bladder wall, which leads to bladder dysfunction. In this paper, we demonstrate that polarized light imaging can be used to identify the location of obstruction induced structural changes that other imaging modalities fail to detect. We induced 2-week and 6-week partial outlet obstruction in rats, harvested obstructed bladders, then measured their retardances while distended to high pressures and compared them to controls. Our results show that the retardance of the central part of the ventral side (above the ureters) closer to the urethra can be used as a potential metric of the distending bladder obstruction. (C) 2014 Optical Society of America

引用

页码：621 / 629

页数：9

共 38 条

[21] Regional biomechanical and histological characterisation of the passive porcine urinary bladder: Implications for augmentation and tissue engineering strategies [J].