Immunological basis of virus-host interaction in COVID-19

被引：6

作者：

La Torre, Francesco ^{[1
]}

Leonardi, Lucia ^{[2
]}

Giardino, Giuliana ^{[3
]}

Volpi, Stefano ^{[4
]}

Federici, Silvia ^{[5
]}

Soresina, Annarosa ^{[6
]}

Cancrini, Caterina ^{[7
]}

Lougaris, Vassilios ^{[8
,9
,10
]}

Castagnoli, Riccardo ^{[11
]}

Corrente, Stefania ^{[12
]}

Cardinale, Fabio ^{[1
]}

机构：

[1] Giovanni XXIII Pediat Hosp, Dept Pediat, Bari, Italy

[2] Univ Roma Tor Vergata, Dept Syst Med, Rome, Italy

[3] Univ Naples Federico II, Dept Translat Med Sci, Pediat Sect, Naples, Italy

[4] Univ Genoa, IRCCS Ist Giannina Gaslini, Ctr Autoinflammatory Dis & Immunodeficiency, Genoa, Italy

[5] Osped Pediat Bambino Gesu, Div Rheumatol, IRCCS, Rome, Italy

[6] ASST Spedali Civili Brescia, Pediat Clin, Brescia, Italy

[7] IRCCS, Bambino Gesu Childrens Hosp, Res Unit Primary Immunodeficiencies, Acad Dept Pediat,Immune & Infect Dis Div, Rome, Italy

[8] Univ Brescia, Pediat Clin, Dept Clin & Expt Sci, Brescia, Italy

[9] Univ Brescia, Inst Mol Med A Nocivelli, Brescia, Italy

[10] ASST Spedali Civili Brescia, Brescia, Italy

[11] Univ Pavia, Pediat Clin, Fdn IRCCS Policlin San Matteo, Dept Pediat, Pavia, Italy

[12] Azienda Osped San Camillo Forlanini, Pediat Dept, Rome, Italy

来源：

PEDIATRIC ALLERGY AND IMMUNOLOGY | 2020年 / 31卷

关键词：

children; COVID-19; cytokine storm; immunopathogenesis; Kawasaki disease;

D O I：

10.1111/pai.13363

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

COVID-19 is a complex new viral disease, in which a strict balance between anti-viral immune response and the ensuing organ inflammation has a critical role in determining the clinical course. In adults, compelling evidence exists indicating that an uncontrolled inflammatory response ("cytokine storm") is pivotal in determining disease progression and mortality. Children may rarely present with severe disease. Modulating factors related to the host's genetic factors, age-related susceptibility, and the capability to mount appropriate immune responses might play a role in control virus load at an early stage and regulating the inflammatory reaction. Elucidating these mechanisms seems crucial in developing target therapies according to patient's age, immunologic status, and disease evolution in COVID-19.

引用

页码：75 / 78

页数：4

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