Nickel-catalyzed cross-coupling of sterically hindered 1-bromomethyl-o-carborane with alkyl and aryl Grignard reagents

被引：11

作者：

Lu, Juyou ^{[1
]}

Wan, Hong ^{[1
]}

Xue, Yunna ^{[1
]}

Du, Yongmei ^{[1
]}

Lu, Jian ^{[1
]}

机构：

[1] Xian Modern Chem Res Inst, Xian 710065, Peoples R China

来源：

TETRAHEDRON | 2015年 / 71卷 / 41期

基金：

中国国家自然科学基金;

关键词：

Nikel-catalyzed; Cross-coupling; Carborane; Grignard reagent; Sterically hindered; O-CARBORANE; DECABORANE; CHEMISTRY; DERIVATIVES; SOLVENT; HALIDES; ROUTE;

D O I：

10.1016/j.tet.2015.08.022

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient and efficient Ni-catalyzed reaction has been developed for synthesis of mono-substituted o-carboranes, involving cross-coupling of readily available and sterically hindered 1-bromomethyl-o-carborane with various alkyl and aryl Grignard reagents under mild conditions, and the corresponding o-carborane derivatives were obtained in good to excellent yields. This method should provide a new strategy for construction of diverse and useful functionalized boron cluster compounds for medicinal chemistry and material chemistry. (c) 2015 Elsevier Ltd. All rights reserved.

引用

页码：7842 / 7846

页数：5

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