An Electrocorticographic Brain Interface in an Individual with Tetraplegia

被引：248

作者：

Wang, Wei ^{[1
,2
,3
,4
,5
]}

Collinger, Jennifer L. ^{[1
,2
,6
]}

Degenhart, Alan D. ^{[2
,4
,5
]}

Tyler-Kabara, Elizabeth C. ^{[1
,2
,7
]}

Schwartz, Andrew B. ^{[1
,2
,4
,5
,8
]}

Moran, Daniel W. ^{[9
,10
]}

Weber, Douglas J. ^{[1
,2
,4
,5
,6
]}

Wodlinger, Brian ^{[1
,4
,5
]}

Vinjamuri, Ramana K. ^{[1
]}

Ashmore, Robin C. ^{[1
]}

Kelly, John W. ^{[11
]}

Boninger, Michael L. ^{[1
,2
,3
,6
]}

机构：

[1] Univ Pittsburgh, Dept Phys Med & Rehabil, Pittsburgh, PA 15260 USA

[2] Univ Pittsburgh, Dept Bioengn, Pittsburgh, PA USA

[3] Univ Pittsburgh, Clin & Translat Sci Inst, Pittsburgh, PA USA

[4] Carnegie Mellon Univ, Ctr Neural Basis Cognit, Pittsburgh, PA 15213 USA

[5] Univ Pittsburgh, Pittsburgh, PA USA

[6] Dept Vet Affairs, Human Engn Res Labs, Pittsburgh, PA USA

[7] Univ Pittsburgh, Dept Neurol Surg, Pittsburgh, PA 15260 USA

[8] Univ Pittsburgh, Dept Neurobiol, Pittsburgh, PA USA

[9] Washington Univ, Dept Biomed Engn, St Louis, MO USA

[10] Washington Univ, Dept Neurobiol, St Louis, MO USA

[11] Carnegie Mellon Univ, Dept Elect & Comp Engn, Pittsburgh, PA 15213 USA

来源：

PLOS ONE | 2013年 / 8卷 / 02期

基金：

美国国家卫生研究院;

关键词：

MOTOR CORTICAL REPRESENTATION; MOVEMENT TRAJECTORIES; COMPUTER INTERFACE; CORTEX; SIGNALS; EXECUTION; DIRECTION; IMAGERY; ARM;

D O I：

10.1371/journal.pone.0055344

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Brain-computer interface (BCI) technology aims to help individuals with disability to control assistive devices and reanimate paralyzed limbs. Our study investigated the feasibility of an electrocorticography (ECoG)-based BCI system in an individual with tetraplegia caused by C4 level spinal cord injury. ECoG signals were recorded with a high-density 32-electrode grid over the hand and arm area of the left sensorimotor cortex. The participant was able to voluntarily activate his sensorimotor cortex using attempted movements, with distinct cortical activity patterns for different segments of the upper limb. Using only brain activity, the participant achieved robust control of 3D cursor movement. The ECoG grid was explanted 28 days post-implantation with no adverse effect. This study demonstrates that ECoG signals recorded from the sensorimotor cortex can be used for real-time device control in paralyzed individuals.

引用

页数：8

共 54 条

[1]

Acharya S, 2010, J NEURAL ENG, V7, DOI [10.1088/1741-2560/7/4/046002, 10.2202/1553-3840.1324]

[2]

American Spinal Injury Association/International Medical Society of Paraplegia, 2001, INT STAND NEUR FUNCT

[3]

Ashmore RC, 2012, STABLE ONLINE CONTRO

[4] Robust, long-term control of an electrocorticographic brain-computer interface with fixed parameters [J].