Structure and function of the epidermal barrier in patients with atopic dermatitis - treatment options. Part one

被引：12

作者：

Pelc, Jagoda ^{[1
]}

Czarnecka-Operacz, Magdalena ^{[1
]}

Adamski, Zygmunt ^{[1
]}

机构：

[1] Poznan Univ Med Sci, Dept Dermatol & Venereol, 49 Przybyszewskiego St, PL-60355 Poznan, Poland

来源：

POSTEPY DERMATOLOGII I ALERGOLOGII | 2018年 / 35卷 / 01期

关键词：

atopic dermatitis; epidermal barrier; filaggrin; cytokines; IMMUNE DYSREGULATION; SKIN BARRIER; FILAGGRIN; DISEASE;

D O I：

10.5114/ada.2018.73159

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Atopic dermatitis is a chronic, recurrent inflammatory skin disease, which is frequently familial. The main cause of the disease seems to be a defect of the epidermal barrier resulting from a genetic predisposition concerning the epidermis, functioning of the immune system as well as environmental factors (which are not related to the immune system). Genes responsible for encoding protein S100, filaggrin, proteases and their inhibitors are the main genes related to the problem of epidermal barrier dysfunction. There is a close connection between structural and immunological processes. Increased expression of cytokine Th2 profile belongs to the latter category. The objective of the present paper is to describe the influence of aforementioned factors on epidermis structure and dysfunction which leads to clinical symptoms of atopic dermatitis.

引用

页码：1 / 5

页数：5

共 15 条

[1] Diagnosis and treatment of atopic dermatitis in children and adults: European Academy of Allergology and Clinical Immunology/American Academy of Allergy, Asthma and Immunology/PRACTALL consensus report [J].

Akdis, C. A. ;

Akdis, M. ;

Bieber, T. ;

Bindslev-Jensen, C. ;

Boguniewicz, M. ;

Eigenmann, P. ;

Hamid, Q. ;

Kapp, A. ;

Leung, D. Y. M. ;

Lipozencic, J. ;

Luger, T. A. ;

Muraro, A. ;

Novak, N. ;

Platts-Mills, T. A. E. ;

Rosenwasser, L. ;

Scheynius, A. ;

Simons, F. E. R. ;

Spergel, J. ;

Turjanmaa, K. ;

Wahn, U. ;

Weidinger, S. ;

Werfel, T. ;

Zuberbier, T. .

ALLERGY, 2006, 61 (08) :969-987

[2] Atopic dermatitis: a disease of altered skin barrier and immune dysregulation [J].

Boguniewicz, Mark ;

Leung, Donald Y. M. .

IMMUNOLOGICAL REVIEWS, 2011, 242 :233-246

[3] Epidermal Barrier Dysfunction in Atopic Dermatitis [J].

Cork, Michael J. ;

Danby, Simon G. ;

Vasilopoulos, Yiannis ;

Hadgraft, Jonathan ;

Lane, Majella E. ;

Moustafa, Manar ;

Guy, Richard H. ;

MacGowan, Alice L. ;

Tazi-Ahnini, Rachid ;

Ward, Simon J. .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2009, 129 (08) :1892-1908

[4] The frequency of polymorphic variants of filaggrin gene and clinical atopic dermatitis [J].

Filipowska-Gronska, Agata ;

Werynska-Kalemba, Maria ;

Bozek, Andrzej ;

Filipowska, Barbara ;

Zebracka-Gala, Jadwiga ;

Rusinek, Dagmara ;

Kula, Dorota ;

Jarzab, Jerzy .

POSTEPY DERMATOLOGII I ALERGOLOGII, 2016, 33 (01) :37-41

[5] Emerging role of interleukin-31 and interleukin-31 receptor in pruritus in atopic dermatitis [J].

Furue, M. ;

Yamamura, K. ;

Kido-Nakahara, M. ;

Nakahara, T. ;

Fukui, Y. .

ALLERGY, 2018, 73 (01) :29-36

[6]

Kurowski M, 2009, ALERG ASTMA IMMUNOL, V14, P95

[7] New Insights into Atopic Dermatitis: Role of Skin Barrier and Immune Dysregulation [J].

Leung, Donald Y. M. .

ALLERGOLOGY INTERNATIONAL, 2013, 62 (02) :151-161

[8] Pathogenesis of atopic dermatitis [J].

Leung, DYM .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1999, 104 (03) :S99-S108

[9] The multifunctional role of filaggrin in allergic skin disease [J].

McAleer, Maeve A. ;

Irvine, Alan D. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2013, 131 (02) :280-291

[10] Pathogenesis of atopic dermatitis [J].

Peng, W. ;

Novak, N. .

CLINICAL AND EXPERIMENTAL ALLERGY, 2015, 45 (03) :566-574

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