A Matter of Balance: Role of Neurexin and Neuroligin at the Synapse

被引：71

作者：

Bang, Marie Louise ^{[1
]}

Owczarek, Sylwia ^{[1
,2
]}

机构：

[1] Univ Copenhagen, Prot Lab, Dept Neurosci & Pharmacol, Panum Inst, DK-2200 Copenhagen, Denmark

[2] Bispebjerg Hosp, Res Lab Stereol & Neurosci, DK-2400 Copenhagen, Denmark

来源：

NEUROCHEMICAL RESEARCH | 2013年 / 38卷 / 06期

关键词：

Cell adhesion molecule; Synapse; Synaptic plasticity; Neurodevelopmental disorders; ACTIVITY-DEPENDENT REGULATION; GENE-EXPRESSION ANALYSIS; INHIBITORY SYNAPSES; ALPHA-NEUREXINS; LIGAND-BINDING; POSTSYNAPTIC DIFFERENTIATION; STRUCTURAL VARIANTS; ADHESION MOLECULES; MENTAL-RETARDATION; BETA-NEUREXINS;

D O I：

10.1007/s11064-013-1029-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neurexins and neuroligins are synaptic cell adhesion molecules. Neurexins are primary located on the presynaptic membrane, whereas neuroligins are strictly postsynaptic proteins. Since their discovery, the knowledge of neurexins and neuroligins has expanded, implicating them in various neuronal processes, including the differentiation, maturation, stabilization, and plasticity of both inhibitory and excitatory synapses. Here, we review the most recent results regarding the structure and function of these cell adhesion molecules.

引用

页码：1174 / 1189

页数：16

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