Chemical constituents from Brucea java']javanica

被引：26

作者：

Dong, Shi-Hui ^{[1
]}

Liu, Jia ^{[1
]}

Ge, Ying-Zi ^{[1
]}

Dong, Lei ^{[1
]}

Xu, Cheng-Hui ^{[1
]}

Ding, Jian ^{[1
]}

Yue, Jian-Min ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China

来源：

PHYTOCHEMISTRY | 2013年 / 85卷

关键词：

Brucea [!text type='java']java[!/text]nica; Simaroubaceae; Triterpenoids; Quassinoids; Lignans; Bru[!text type='java']java[!/text]nones A-N; Brucea[!text type='java']java[!/text]nin C; QUASSINOID GLYCOSIDES; STRUCTURAL ELUCIDATION; SEEDS; LIGNANS; TRITERPENOIDS; DERIVATIVES; GLUCOSIDES; APOPTOSIS; FRUITS; AGENTS;

D O I：

10.1016/j.phytochem.2012.08.018

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fourteen apotirucallane-type triterpenoids, named brujavanones A-N, were isolated from the twigs of Brucea javanica, along with four known quassinoids and seven known lignans from the seeds of B. javanica. Their structures were elucidated on the basis of extensive spectroscopic data analysis. The structure of a previously reported triterpenoid, bruceajavanin C, was revised as its C-21 epimer. The cytotoxic activities of triterpenoids and quassinoids against two human tumor cell lines, HL-60 and A-549, were evaluated, but all the compounds were inactive (IC50 > 10 mu M). (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：175 / 184

页数：10

共 51 条

[1] Isolation and characterization of novel benzoates, cinnamates, flavonoids, and lignans from Riesling wine and screening for antioxidant activity [J].