Anisomycin infusions in the parabrachial nucleus and taste neophobia

被引：3

作者：

Lin, Jian-You ^{[1
]}

Amodeo, Leslie Renee ^{[1
]}

Arthurs, Joe ^{[1
]}

Reilly, Steve ^{[1
]}

机构：

[1] Univ Illinois, Dept Psychol, Chicago, IL 60607 USA

来源：

NEUROBIOLOGY OF LEARNING AND MEMORY | 2012年 / 98卷 / 04期

关键词：

Taste neophobia; Memory consolidation; De novo protein synthesis; Parabrachial nucleus; Rat; PROTEIN-SYNTHESIS INHIBITION; REDUCED PALATABILITY; GUSTATORY LESIONS; AVERSION; MEMORY; RATS; RELEASE; AMNESIA; NOREPINEPHRINE; DOPAMINE;

D O I：

10.1016/j.nlm.2012.10.002

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

To investigate whether de nova protein synthesis in the parabrachial nucleus (PBN) is required for recovery from taste neophobia, anisomycin (a protein synthesis inhibitor) was infused immediately after consumption of a novel saccharin solution (Experiment 1). Unexpectedly, this PBN treatment caused a reduction in saccharin intake. In addition, we found that the anisomycin-induced suppression of tastant intake was attenuated by prior intra-PBN infusions of lidocaine (Experiment 2). This pattern of results raises concerns about using anisomycin to investigate memory consolidation processes in the PBN. Thus, a different manipulation may be needed to examine the nature of the neuroplastic changes that occur in the PBN during taste memory formation. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：348 / 353

页数：6

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