Coding rules for amino acids in the genetic code: The genetic code is a minimal code of mutational deterioration

被引：10

作者：

Luo, LF ^{[1
]}

Li, XQ ^{[1
]}

机构：

[1] Inner Mongolia Univ, Dept Phys, Hohhot, Peoples R China

来源：

ORIGINS OF LIFE AND EVOLUTION OF THE BIOSPHERE | 2002年 / 32卷 / 01期

基金：

中国国家自然科学基金;

关键词：

amino acid distance; coding rule; globalmutational deterioration; standard genetic code; optimization under constraints; single base mutation;

D O I：

10.1023/A:1013963505140

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Coding rules for amino acids in the genetic code are discussed from the point that the genetic code is a minimal code of mutational deterioration. The global mutational deterioration (GMD) function is defined through several parameters describing single base mutations and amino acid distances. The problem of searching for the global minimum of the GMD function is discussed in some detail. From GMD minimization under initial constraints we have succeeded in deducing the standard genetic code.

引用

页码：23 / 33

页数：11

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