Crispoic acid, a new compound from Laelia marginata (Orchidaceae), and biological evaluations against parasites, human cancer cell lines and Zika virus

被引：7

作者：

Belloto, Andrezza C. ^{[1
]}

Souza, Gredson K. ^{[1
]}

Perin, Paula C. ^{[1
]}

Schuquel, Ivania T. A. ^{[1
]}

Santin, Silvana M. O. ^{[1
]}

Chiavelli, Lucas U. R. ^{[1
]}

Garcia, Francielle P. ^{[2
]}

Kaplum, Vanessa ^{[2
]}

Rodrigues, Jean H. S. ^{[2
]}

Scariot, Debora B. ^{[2
]}

Delvecchio, Rodrigo ^{[3
]}

Machado-Ferreira, Erik ^{[3
]}

Aguiar, Renato Santana ^{[3
]}

Soares, Carlos A. G. ^{[3
]}

Nakamura, Celso V. ^{[2
]}

Pomini, Armando M. ^{[1
]}

机构：

[1] Univ Estadual Maringa, Dept Quim, Maringa, Parana, Brazil

[2] Univ Estadual Maringa, Dept Ciencias Basicas Saude, Maringa, Parana, Brazil

[3] Univ Fed Rio de Janeiro, Inst Biol, Dept Genet, Rio De Janeiro, Brazil

来源：

NATURAL PRODUCT RESEARCH | 2018年 / 32卷 / 24期

关键词：

Laelia marginata; Leishmania (Leishmania) amazonensis; bioactive metabolites; cytotoxicity; Trypanosoma cruzi; Zika virus; Orchidaceae; CONSTITUENTS;

D O I：

10.1080/14786419.2017.1395428

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The phytochemical study of Laelia marginata (Lindl.) L. O. Williams (Orchidaceae) led to the isolation of a new natural product named crispoic acid (1), together with six other known compounds (2-7). The new natural product was identified as a dimer of eucomic acid and was structurally characterised based upon 1D and 2D NMR and HRMS data. Biological assays with plant crude extract, fractions and isolated compounds were performed against two human cancer cell lines (Hela and Siha), and the tropical parasites Trypanosoma cruzi and Leishmania (Leishmania) amazonensis. The phenantrenoid 9,10-dihydro-4-methoxyphenanthren-2,7-diol 2 was active against Hela and Siha cells (CC50 5.86 +/- 0.19 and 20.78 +/- 2.72 mu g/mL, respectively). Sub-lethal concentrations of the flavone rhamnazin 4 were not able to rescue the viability of the Vero cells infected by Zika virus. [GRAPHICS] .

引用

页码：2916 / 2921

页数：6

共 18 条

[1] Almeida TL, 2014, QUIM NOVA, V37, P1151
[2] Brener Z, 1962, REV INST MED TROP SP, V4, P386
[3] Cell death and ultrastructural alterations in Leishmania amazonensis caused by new compound 4-Nitrobenzaldehyde thiosemicarbazone derived from S-limonene
Britta, Elizandra Aparecida
Scariot, Debora Botura
Falzirolli, Hugo
Ueda-Nakamura, Tania
Silva, Cleuza Conceicao
Dias Filho, Benedito Prado
Borsali, Redouane
Nakamura, Celso Vataru
[J]. BMC MICROBIOLOGY, 2014, 14
[4] C-13 NMR-SPECTRA OF POLYMETHOXYFLAVONOLS AND METHYLENEDIOXYFLAVONOLS
CALVERT, DJ
CAMBIE, RC
DAVIS, BR
[J]. ORGANIC MAGNETIC RESONANCE, 1979, 12 (10): : 583 - 586
[5] Chloroquine, an Endocytosis Blocking Agent, Inhibits Zika Virus Infection in Different Cell Models
Delvecchio, Rodrigo
Higa, Luiza M.
Pezzuto, Paula
Valadao, Ana Luiza
Garcez, Patricia P.
Monteiro, Fabio L.
Loiola, Erick C.
Dias, Andre A.
Silva, Fabio J. M.
Aliota, Matthew T.
Caine, Elizabeth A.
Osorio, Jorge E.
Bellio, Maria
O'Connor, David H.
Rehen, Stevens
de Aguiar, Renato Santana
Savarino, Andrea
Campanati, Loraine
Tanuri, Amilcar
[J]. VIRUSES-BASEL, 2016, 8 (12):
[6] NOMENCLATURAL REVISION OF WEST-INDIAN SPECIES OF SCHOMBURGKIA (ORCHIDACEAE)
JONES, HG
[J]. BULLETIN OF THE TORREY BOTANICAL CLUB, 1976, 103 (03): : 117 - 121
[7] Oncibauerins A and B, new flavanones from Oncidium baueri (Orchidaceae)
Monteiro, Josiane A.
Schuquel, Ivania T. A.
de Almeida, Thiago L.
Santin, Silvana M. de O.
da Silva, Cleuza C.
Chiavelli, Lucas U. R.
Ruiz, Ana L. T. G.
de Carvalho, Joao E.
Vendramini-Costa, Debora B.
Nakamura, Celso V.
Scariot, Debora B.
Kaplum, Vanessa
Faria, Ricardo T.
Pomini, Armando M.
[J]. PHYTOCHEMISTRY LETTERS, 2014, 9 : 141 - 148
[8] RAPID COLORIMETRIC ASSAY FOR CELLULAR GROWTH AND SURVIVAL - APPLICATION TO PROLIFERATION AND CYTO-TOXICITY ASSAYS
MOSMANN, T
[J]. JOURNAL OF IMMUNOLOGICAL METHODS, 1983, 65 (1-2) : 55 - 63
[9] (R)-Eucomic acid, a leaf-opening factor of the model organism, Lotus japonicus
Okada, Masahiro
Park, Sungwook
Koshizawa, Takahiro
Ueda, Minoru
[J]. TETRAHEDRON, 2009, 65 (10) : 2136 - 2141
[10] Chemical constituents of Bombacopsis glabra (Bombacaceae).
Paula, VF
Cruz, MP
Barbosa, LCA
[J]. QUIMICA NOVA, 2006, 29 (02): : 213 - 215

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