Semiconducting Polymer Nanoprobe for In Vivo Imaging of Reactive Oxygen and Nitrogen Species

被引：204
|
作者：
Pu, Kanyi [1 ,2 ]
Shuhendler, Adam J. [1 ,2 ]
Rao, Jianghong [1 ,2 ]
机构：
[1] Stanford Univ, Dept Radiol, Mol Imaging Program Stanford, Stanford, CA 94305 USA
[2] Stanford Univ, Dept Chem, Mol Imaging Program Stanford, Stanford, CA 94305 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 39期
关键词：
biosensors; imaging agents; nanoparticles; polymers; reactive oxygen and nitrogen species; FLUORESCENT-PROBES; QUANTUM DOTS; NITRIC-OXIDE; DESIGN; NANOPARTICLES; DEGRADATION; MECHANISMS; DYES;
D O I：
10.1002/anie.201303420
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Semiconducting polymer nanoparticles are used as a free-radical inert and light-harvesting nanoplatform for in vivo molecular imaging of reactive oxygen and nitrogen species (RONS). This nanoprobe permits detection of RONS in the microenvironment of spontaneous bacterial infection (see picture; FRET=fluorescence resonance energy transfer). Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：10325 / 10329
页数：5
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