Amebicidal effects of fenugreek (Trigonella foenum-graecum) against Acanthamoeba cysts

被引：8
|
作者：
Kaya, Yasemin [1 ]
Baldemir, Ayse [2 ]
Karaman, Ulku [3 ]
Ildiz, Nilay [4 ]
Arici, Yeliz Kasko [5 ]
Kacmaz, Gamze [6 ]
Koloren, Zeynep [7 ]
Konca, Yusuf [8 ]
机构：
[1] Ordu Univ, Fac Med, Dept Internal Med, Ordu, Turkey
[2] Erciyes Univ, Dept Pharmaceut Bot, Fac Pharm, Kayseri, Turkey
[3] Ordu Univ, Med Parasitol Dept, Fac Med, Ordu, Turkey
[4] Erciyes Univ, Dept Pharmaceut Microbiol, Fac Pharm, Kayseri, Turkey
[5] Ordu Univ, Fac Med, Biostat Dept, Ordu, Turkey
[6] Giresun Univ, Med Microbiol Dept, Fac Med, Giresun, Turkey
[7] Ordu Univ, Dept Biol, Fac Arts & Sci, Ordu, Turkey
[8] Erciyes Univ, Dept Feed & Anim Feeding, Fac Agr, Kayseri, Turkey
来源：
FOOD SCIENCE & NUTRITION | 2019年 / 7卷 / 02期
关键词：
Acanthamoeba castellanii; amebicidal effect; fenugreek; Trigonella foenum-graecum; IN-VITRO EVALUATION; CASTELLANII CYSTS; CYTOTOXIC POTENTIALS; UNCOUPLING PROTEIN; SEEDS; KERATITIS; L; ENCEPHALITIS; ANTIOXIDANT; COMBINATION;
D O I：
10.1002/fsn3.849
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Trigonella foenum-graecum L. (TF) is known to the public as a chest emollient, mucous expectorant, laxative and is used to prevent maturation of boils and diabetes since ancient times. In this study, we aimed to determine the amebicidal effects against Acanthamoeba cysts. Plant extracts were prepared at concentrations of 1, 2, 4, 8, 16, and 32 mg/ml and were placed in a hemocytometer with cell counts 22 x 10(6) cell/ml. The fatty acid profiles of TF seeds were determined. Standard Acanthamoeba cysts were added and incubated at 25 degrees C. The viability of the parasite was checked and recorded at hours 3, 24, 48, 72, 96, and 102. The values of lethal concentration doses (LD50 and LD90) were calculated using probit analysis. This study revealed that T. foenum-graecum prevented proliferation of the parasite at certain times. However, further for in vivo and controlled experimental studies are needed in order to find out how to use this plant as medication.
引用
收藏
页码：563 / 571
页数：9
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