Chemical constituents from the roots of Nauclea orientalis

被引：13

作者：

Sichaem, Jirapast ^{[1
,2
]}

Worawalai, Wisuttaya ^{[1
]}

Tip-pyang, Santi ^{[1
]}

机构：

[1] Chulalongkorn Univ, Fac Sci, Dept Chem, Nat Prod Res Unit, Bangkok 10330, Thailand

[2] Chulalongkorn Univ, Ctr Petr Petrochem & Adv Mat, Bangkok 10330, Thailand

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2012年 / 48卷 / 05期

关键词：

Nauclea orientalis; Rubiaceae; naucleidinal derivative; cytotoxic activities; INDOLE ALKALOIDS; STEMS;

D O I：

10.1007/s10600-012-0393-z

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new naucleidinal derivative 4 along with nine known compounds constisting of six indole alkaloids [naucleficine (1), naucleactonin A (2), naucleidinal (3), 19-epi-naucleidinal (5), strictosamide (6), and pumiloside (7)], two secoiridoids [aligenoside (8) and sweroside (9)], and vanillic acid (10) were isolated from the roots of Nauclea orientalis. The structures of all isolated compounds were elucidated from their physical properties and by spectroscopic methods as well as comparison with previous literature data. Compounds 1-5 and 8-10 were isolated for the first time from this plant. In addition, the isolated compounds were tested for cytotoxicity on HeLa and KB cell lines.

引用

页码：827 / 830

页数：4

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