The Seville Expert Workshop for Progress in Posttransplant Lymphoproliferative Disorders

被引：39

作者：

Glotz, Denis ^{[1
]}

Chapman, Jeremy R. ^{[2
]}

Dharnidharka, Vikas R. ^{[3
,4
]}

Hanto, Douglas W. ^{[5
,6
]}

Castro, Maria C. R. ^{[7
,8
]}

Hirsch, Hans H. ^{[9
,10
]}

Leblond, Veronique ^{[11
,12
]}

Mehta, Aneesh K. ^{[13
]}

Moulin, Bruno ^{[14
]}

Pagliuca, Antonio ^{[15
]}

Pascual, Julio ^{[16
]}

Rickinson, Alan B. ^{[17
]}

Russo, Francesco P. ^{[18
]}

Trappe, Ralf U. ^{[19
]}

Webster, Angela C. ^{[2
]}

Zuckermann, Andreas O. ^{[20
]}

Gross, Thomas G. ^{[21
]}

机构：

[1] Hop St Louis, Nephrol & Transplantat Serv, F-75010 Paris, France

[2] Univ Sydney, Westmead Hosp, Ctr Transplantat & Renal Res, Westmead, NSW 2145, Australia

[3] Univ Florida, Div Pediat Nephrol, Gainesville, FL USA

[4] Shands Childrens Hosp, Gainesville, FL USA

[5] Beth Israel Deaconess Med Ctr, Transplant Inst, Boston, MA 02215 USA

[6] Harvard Univ, Sch Med, Boston, MA USA

[7] Univ Sao Paulo, Immunol Lab, Sao Paulo, Brazil

[8] Univ Sao Paulo, Kidney Transplantat Unit, Sao Paulo, Brazil

[9] Univ Basel, Dept Biomed, Basel, Switzerland

[10] Univ Basel Hosp, Div Infect Dis, CH-4031 Basel, Switzerland

[11] Univ Paris 06, GRC N 11, GRECHY, Paris, France

[12] Hop La Pitie Salpetriere, AP HP, Dept Haematol, Paris, France

[13] Emory Univ, Sch Med, Div Infect Dis, Atlanta, GA USA

[14] Univ Hosp Strasbourg, Nephrol & Renal Transplantat Dept, Strasbourg, France

[15] Kings Coll London, Dept Haematol Med, London WC2R 2LS, England

[16] Hosp Mar, Dept Nephrol, Barcelona, Spain

[17] Univ Birmingham, Sch Canc Sci, Birmingham, W Midlands, England

[18] Univ Hosp Padua, Gastroenterol & Multivisceral Transplant Unit, Dept Surg Oncol & Gastroenterol Sci, Padua, Italy

[19] Univ Med Ctr Schleswig Holstein, Dept Internal Med Hematol & Oncol 2, Kiel, Germany

[20] Med Univ Vienna, Dept Cardiac Surg, Vienna, Austria

[21] Nationwide Childrens Hospi, Div Hematol Oncol BMT, Columbus, OH USA

来源：

TRANSPLANTATION | 2012年 / 94卷 / 08期

关键词：

Epstein-Barr virus infection; Immunosuppression; Lymphoproliferative disorder; Transplantation; EPSTEIN-BARR-VIRUS; SOLID-ORGAN TRANSPLANTATION; NON-HODGKIN-LYMPHOMA; PEDIATRIC KIDNEY-TRANSPLANTATION; RENAL-TRANSPLANTATION; RISK-FACTORS; LIVER-TRANSPLANTATION; UNITED-STATES; COLLABORATIVE TRANSPLANT; DISEASE;

D O I：

10.1097/TP.0b013e318269e64f

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Posttransplant lymphoproliferative disorders (PTLDs) are associated with significant morbidity and mortality among solid-organ transplant patients, but approaches to diagnosis and management vary considerably. An international multidisciplinary panel evaluated current understanding of risk factors and classification systems and developed recommendations to aid in PTLD prevention. We considered evidence on PTLD risk factors including Epstein- Barr virus serostatus and immunosuppression and identified knowledge gaps for future research. Recommendations address prophylactic and preemptive strategies to minimize PTLD development, including modulation of immunosuppression and antiviral drug regimens. Finally, new classification criteria were outlined that may help facilitate standardized reporting and improve our understanding of PTLD.

引用

页码：784 / 793

页数：10

共 85 条

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