Hepatitis B and C virus infection in patients with Systemic and Cutaneous Lupus Erythematosus

被引：0

作者：

Lo Presti, Alessandra ^{[1
]}

Ceccarelli, Fulvia ^{[2
]}

Dorrucci, Maria ^{[1
]}

Farchi, Francesca ^{[1
]}

Pirone, Carmelo ^{[2
]}

Garufi, Cristina ^{[2
]}

Valdarchi, Catia ^{[1
]}

Spinelli, Francesca Romana ^{[2
]}

Alessandri, Cristiano ^{[2
]}

Chionne, Paola ^{[1
]}

Madonna, Elisabetta ^{[1
]}

Pisani, Giulio ^{[3
]}

Martina, Antonio ^{[3
]}

Simeoni, Matteo ^{[3
]}

Bruni, Roberto ^{[1
]}

Ciccozzi, Massimo ^{[4
]}

Iaiani, Giancarlo ^{[5
]}

Ciccaglione, Anna Rita ^{[1
]}

Spada, Enea ^{[1
]}

Conti, Fabrizio ^{[2
]}

机构：

[1] Ist Super Sanitet, Dept Infect Dis, Rome, Italy

[2] Sapienza Univ Roma, Dipartimento Sci Clin Internist Anestesiol & Cardi, Lupus Clin, Rheumatol, Rome, Italy

[3] Natl Inst Hlth, Ctr Immunobiol Res & Evaluat, Rome, Italy

[4] Univ Campus Biomed Rome, Unit Med Stat & Mol Epidemiol, Selcetta, Italy

[5] Aou Policlin Umberto 1, Dept Trop & Infect Dis, Rome, Italy

来源：

NEW MICROBIOLOGICA | 2022年 / 45卷 / 04期

关键词：

Hepatitis B virus; Hepatitis C virus; Systemic lupus erythematosus; Cutaneous Lupus; Serological; epidemiological evaluation; PREVALENCE; DISEASES; INDEX;

D O I：

暂无

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by a multifactorial etiology. The primary aim of this study was to estimate HCV and HBV infection prevalence in a cohort of SLE and Cutaneous Lupus Erythematosus (CLE). We assessed the frequency of these infections in our cohort and the possible associations with disease clinical/laboratory features and disease activity status. The prevalence of chronic HBV infection was 2.2% in the CLE group, while no HBsAg positive patients were identified in the SLE group. Conversely, the prevalence of anti-HCV positive was 2.2% in the SLE group while no anti-HCV positive patients were identified in the CLE group. We found no significant association between anti-HBc positive status and clinical manifestations or disease activity status in either group of patients. Hemodialysis resulted significantly associated with anti-HBc positivity in SLE. In the present study, we found HBsAg positivity in CLE patients but not in the Systemic form (SLE); conversely, a similar prevalence of anti-HBc antibodies in both groups was observed. A possible protective role exerted by SLE in HBV infection may be hypothesized. A higher frequency of HCV infection in SLE compared to CLE suggests a possible involvement of HCV in some SLE-related clinical and immunological features.

引用

页码：296 / 303

页数：8

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[41] Blood Pressure Variability and Age-related Blood Pressure Patterns in Systemic Lupus Erythematosus [J].