A unimolecular G-quadruplex that functions as a synthetic transmembrane Na+ transporter

被引：166

作者：

Kaucher, MS ^{[1
]}

Harrell, WA ^{[1
]}

Davis, JT ^{[1
]}

机构：

[1] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 01期

关键词：

D O I：

10.1021/ja056888e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We describe the covalent post-modification of a hydrogen-bonded assembly with the subsequent formation of a potent transmembrane Na+ ion transporter. Olefin metathesis is used to cross-link all 16 guanosine subunits in a lipophilic G-quadruplex. The resulting unimolecular G-quadruplex folds in the environment of a phospholipid membrane and functions as a Na+ ion transporter as judged by fluorescence and 23Na NMR transport assays. Copyright © 2006 American Chemical Society.

引用

页码：38 / 39

页数：2

共 26 条

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