Zinc chloride-catalyzed one-pot, three-component synthesis of 5,8-dihydro-5,8-dioxo-4H-chromene derivatives

被引:5
作者
Srinivas, Vakiti [1 ]
Rao, Vedula Rajeswar [1 ]
机构
[1] Natl Inst Technol, Dept Chem, Warangal, Andhra Pradesh, India
关键词
EMBELIN; INHIBITOR; APOPTOSIS; RATS;
D O I
10.1002/jhet.849
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
An efficient zinc chloride-catalyzed one-pot synthesis of 5,8-dihydro-5,8-dioxo-4H-chromene derivatives have been achieved by the reaction of 2,5-dihydroxy-6-undecyl-1,4-bezoquinone, cyanothioacetamide, and aromaticaldehyde, in EtOH at room temperature. The structures of the products were characterized by IR, 1H-NMR, mass spectra, and elemental analyses. J. Heterocyclic Chem., (2011).
引用
收藏
页码:417 / 420
页数:4
相关论文
共 14 条
[1]  
[Anonymous], 2006, J CARCINOG, DOI DOI 10.1186/1477-3163-5-14
[2]   Design, synthesis, and characterization of new embelin derivatives as potent inhibitors of X-linked inhibitor of apoptosis protein [J].
Chen, Jianyong ;
Nikolovska-Coleska, Zaneta ;
Wang, Guoping ;
Qiu, Su ;
Wang, Shaomeng .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (22) :5805-5808
[3]  
Dewick P., 2002, Medicinal Natural Products. A Biosynthetic Approach
[4]  
DRISCOLL JS, 1974, CANCER CHEMOTH REP 3, V4, P1
[5]  
Liu KKC, 2004, MINI-REV MED CHEM, V4, P1105
[6]   Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XLAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database [J].
Nikolovska-Coleska, Z ;
Xu, L ;
Hu, ZJ ;
Tomita, Y ;
Li, P ;
Roller, PP ;
Wang, RX ;
Fang, XL ;
Guo, RB ;
Zhang, MC ;
Lippman, ME ;
Yang, DJ ;
Wang, SM .
JOURNAL OF MEDICINAL CHEMISTRY, 2004, 47 (10) :2430-2440
[7]   Cytotoxic activity of embelin from Lysimachia punctata [J].
Podolak, I ;
Galanty, A ;
Janeczko, Z .
FITOTERAPIA, 2005, 76 (3-4) :333-335
[8]   Facile one-pot synthesis of 3-{2-[5-hydroxy-4-(2-hydroxy-ethyl)-3-methyl-pyrazol-1-yl]-thiazol-4-yl}-chromen-2-ones via a three-component reaction [J].
Rao, V. Rajeswar ;
Kumar, P. Vijaya .
SYNTHETIC COMMUNICATIONS, 2006, 36 (15) :2157-2161
[9]  
Shiah SG, 1999, CANCER RES, V59, P391
[10]   Chemopreventive effects of embelin and curcumin against N-nitrosodiethylamine/phenobarbital-induced hepatocarcinogenesis in Wistar rats [J].
Sreepriya, M ;
Bali, G .
FITOTERAPIA, 2005, 76 (06) :549-555