The A4 Study: Stopping AD Before Symptoms Begin?

被引：573

作者：

Sperling, Reisa A. ^{[1
,2
]}

Rentz, Dorene M. ^{[1
,2
]}

Johnson, Keith A. ^{[1
,2
,3
]}

Karlawish, Jason ^{[4
]}

Donohue, Michael ^{[5
]}

Salmon, David P. ^{[5
]}

Aisen, Paul ^{[5
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Ctr Alzheimer Res & Treatment,Dept Neurol, Boston, MA 02115 USA

[2] Harvard Aging Brain Study, Dept Neurol, Boston, MA 02114 USA

[3] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02114 USA

[4] Univ Penn, Dept Med Eth & Hlth Policy, Philadelphia, PA 19104 USA

[5] Univ Calif San Diego, Alzheimer Dis Cooperat Study, La Jolla, CA 92093 USA

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2014年 / 6卷 / 228期

关键词：

PRECLINICAL ALZHEIMERS-DISEASE; RISK;

D O I：

10.1126/scitranslmed.3007941

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A new secondary prevention trial in older people with amyloid accumulation at high risk for Alzheimer's disease dementia should provide insights into whether anti-amyloid therapy can delay cognitive decline.

引用

页数：3

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