The A4 Study: Stopping AD Before Symptoms Begin?

被引：559
作者：
Sperling, Reisa A. [1 ,2 ]
Rentz, Dorene M. [1 ,2 ]
Johnson, Keith A. [1 ,2 ,3 ]
Karlawish, Jason [4 ]
Donohue, Michael [5 ]
Salmon, David P. [5 ]
Aisen, Paul [5 ]
机构：
[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Ctr Alzheimer Res & Treatment,Dept Neurol, Boston, MA 02115 USA
[2] Harvard Aging Brain Study, Dept Neurol, Boston, MA 02114 USA
[3] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02114 USA
[4] Univ Penn, Dept Med Eth & Hlth Policy, Philadelphia, PA 19104 USA
[5] Univ Calif San Diego, Alzheimer Dis Cooperat Study, La Jolla, CA 92093 USA
来源：
SCIENCE TRANSLATIONAL MEDICINE | 2014年 / 6卷 / 228期
关键词：
PRECLINICAL ALZHEIMERS-DISEASE; RISK;
D O I：
10.1126/scitranslmed.3007941
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
A new secondary prevention trial in older people with amyloid accumulation at high risk for Alzheimer's disease dementia should provide insights into whether anti-amyloid therapy can delay cognitive decline.
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页数：3
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  • [1] Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease
    Bateman, Randall J.
    Xiong, Chengjie
    Benzinger, Tammie L. S.
    Fagan, Anne M.
    Goate, Alison
    Fox, Nick C.
    Marcus, Daniel S.
    Cairns, Nigel J.
    Xie, Xianyun
    Blazey, Tyler M.
    Holtzman, David M.
    Santacruz, Anna
    Buckles, Virginia
    Oliver, Angela
    Moulder, Krista
    Aisen, Paul S.
    Ghetti, Bernardino
    Klunk, William E.
    McDade, Eric
    Martins, Ralph N.
    Masters, Colin L.
    Mayeux, Richard
    Ringman, John M.
    Rossor, Martin N.
    Schofield, Peter R.
    Sperling, Reisa A.
    Salloway, Stephen
    Morris, John C.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2012, 367 (09) : 795 - 804
  • [2] Risk disclosure and preclinical Alzheimer's disease clinical trial enrollment
    Grill, Joshua D.
    Karlawish, Jason
    Elashoff, David
    Vickrey, Barbara G.
    [J]. ALZHEIMERS & DEMENTIA, 2013, 9 (03) : 356 - 359
  • [3] Memory impairment, executive dysfunction, and intellectual decline in preclinical Alzheimer's disease
    Grober, Ellen
    Hall, Charles B.
    Lipton, Richard B.
    Zonderman, Alan B.
    Resnick, Susan M.
    Kawas, Claudia
    [J]. JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY, 2008, 14 (02) : 266 - 278
  • [4] Regulatory Innovation and Drug Development for Early-Stage Alzheimer's Disease
    Kozauer, Nicholas
    Katz, Russell
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2013, 368 (13) : 1169 - 1171
  • [5] Brain imaging and fluid biomarker analysis in young adults at genetic risk for autosomal dominant Alzheimer's disease in the presenilin 1 E280A kindred: a case-control study
    Reiman, Eric M.
    Quiroz, Yakeel T.
    Fleisher, Adam S.
    Chen, Kewei
    Velez-Pardo, Carlos
    Jimenez-Del-Rio, Marlene
    Fagan, Anne M.
    Shah, Aarti R.
    Alvarez, Sergio
    Arbelaez, Andres
    Giraldo, Margarita
    Acosta-Baena, Natalia
    Sperling, Reisa A.
    Dickerson, Brad
    Stern, Chantal E.
    Tirado, Victoria
    Munoz, Claudia
    Reiman, Rebecca A.
    Huentelman, Matthew J.
    Alexander, Gene E.
    Langbaum, Jessica B. S.
    Kosik, Kenneth S.
    Tariot, Pierre N.
    Lopera, Francisco
    [J]. LANCET NEUROLOGY, 2012, 11 (12) : 1048 - 1056
  • [6] Face-name associative memory performance is related to amyloid burden in normal elderly
    Rentz, Dorene M.
    Amariglio, Rebecca E.
    Becker, J. Alex
    Frey, Meghan
    Olson, Lauren E.
    Frishe, Katherine
    Carmasin, Jeremy
    Maye, Jacqueline E.
    Johnson, Keith A.
    Sperling, Reisa A.
    [J]. NEUROPSYCHOLOGIA, 2011, 49 (09) : 2776 - 2783
  • [7] Testing the Right Target and Right Drug at the Right Stage
    Sperling, Reisa A.
    Jack, Clifford R., Jr.
    Aisen, Paul S.
    [J]. SCIENCE TRANSLATIONAL MEDICINE, 2011, 3 (111)
  • [8] Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
    Sperling, Reisa A.
    Aisen, Paul S.
    Beckett, Laurel A.
    Bennett, David A.
    Craft, Suzanne
    Fagan, Anne M.
    Iwatsubo, Takeshi
    Jack, Clifford R., Jr.
    Kaye, Jeffrey
    Montine, Thomas J.
    Park, Denise C.
    Reiman, Eric M.
    Rowe, Christopher C.
    Siemers, Eric
    Stern, Yaakov
    Yaffe, Kristine
    Carrillo, Maria C.
    Thies, Bill
    Morrison-Bogorad, Marcelle
    Wagster, Molly V.
    Phelps, Creighton H.
    [J]. ALZHEIMERS & DEMENTIA, 2011, 7 (03) : 280 - 292
  • [9] Stark S. M., LEARN MEM, P284
  • [10] Statins for the primary prevention of cardiovascular disease
    Taylor, Fiona
    Ward, Kirsten
    Moore, Theresa H. M.
    Burke, Margaret
    Smith, George Davey
    Casas, Juan-Pablo
    Ebrahim, Shah
    [J]. COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2011, (01):
1