Ubiquitin chained and crosslinked

被引：27

作者：

Finley, D ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

来源：

NATURE CELL BIOLOGY | 2002年 / 4卷 / 05期

关键词：

D O I：

10.1038/ncb0502-e121

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Polyubiquitin chains are assembled onto proteins destined for degradation. The target protein is then unfolded by the proteasome and translocated through a channel leading from the unfolding site to an internal chamber of the enzyme for hydrolysis. A recent paper illuminates the long-elusive polyubiquitin chain recognition step that initiates this sequence of events at the proteasome.

引用

页码：E121 / E123

页数：3

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