Growth hormone as a new treatment modality for short children with chronic renal failure

被引：8
作者：
Mehls, O
Haffner, D
Wuhl, E
Tonshoff, B
Schaefer, F
Heinrich, U
Bittner, K
Ehrich, JHH
Filler, G
Gellermann, J
Hampel, H
Bachmann, H
Ruder, H
Bonzel, KE
Scheller, B
Dippell, J
Zimmerhackl, LB
Kreuder, J
Rascher, W
MullerWiefel, DE
Misselwitz, J
Ronnefarth, B
Querfeld, U
Eichstadt, H
Greiner, C
Keller, E
Weber, HP
Heise, HR
Wiemann, D
Beetz, R
Sasse, D
Soergel, M
Pistor, K
Zlotkowski, A
Klare, B
Eife, R
KuwertzBroking, E
Wigger, M
Mix, M
Eicher, O
机构：
[1] Division of Pediatric Nephrology, University Children’s Hospital of Heidelberg
来源：
HORMONE RESEARCH | 1996年 / 46卷 / 4-5期
关键词：
chronic renal failure; dialysis; renal transplantation; growth failure; growth hormone;
D O I：
10.1159/000185028
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Recombinant human growth hormone (rhGH) has become a new treatment modality for short children with chronic renal failure (CRF) and after renal transplantation. The rationale for high-dose rhGH treatment is the insensitivity of the uremic organism to GH. As the insensitivity to GH is expressed more in end-stage renal failure than in earlier stages of CRF, patients on dialysis respond less to rhGH. In transplanted children, rhGH can counterbalance the growth-depressing effects of corticosteroids, In prepubertal children, rhGH improves the height standard deviation score by a mean of +2 within 5 years. The effect of rhGH treatment on final height remains to be studied.
引用
收藏
页码：230 / 235
页数：6
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