Thumb Imprint Based Detection of Hyperbilirubinemia Using Luminescent Gold Nanoclusters

被引：20

作者：

Basu, Srestha ^{[1
]}

Sahoo, Amaresh Kumar ^{[2
]}

Paul, Anumita ^{[1
]}

Chattopadhyay, Arun ^{[1
,2
]}

机构：

[1] Indian Inst Technol Guwahati, Dept Chem, Gauhati 781039, India

[2] Indian Inst Technol Guwahati, Ctr Nanotechnol, Gauhati 781039, India

来源：

SCIENTIFIC REPORTS | 2016年 / 6卷

关键词：

SERUM-ALBUMIN; BILIRUBIN; COPPER;

D O I：

10.1038/srep39005

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Early and easy detection of diseases, using point-of-care and inexpensive devices, not only provides option for early treatment but also reduces the risk of propagation. Herein we report the fabrication of a robust film based luminescence indicator of bilirubin, which can indicate hyperbilirubinemia through the thumb imprint of the patient. The UV-light induced luminescence intensity of the film, made out of chitosan stabilised gold (Au) nanoclusters, which was effectively quenched in the presence of Cu2+ ions, recovered in the presence of bilirubin from skin or blood serum. Moreover, the sensitivity of detection of bilirubin was tuneable with the amount of Cu2+ added, thereby facilitating the detection of the desired concentration range of bilirubin.

引用

页数：7

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