Importance of vascular endothelial growth factor (VEGF) in ovarian physiology of mammals

被引：47
作者：
Araujo, Valdevane Rocha [1 ]
Graca Duarte, Ana Beatriz [1 ]
Bruno, Jamily Bezerra [1 ]
Pinho Lopes, Claudio Afonso [1 ]
de Figueiredo, Jose Ricardo [1 ]
机构：
[1] Univ Estadual Ceara, Lab Manipulat Oocytes & Preantral Follicles, BR-60740930 Fortaleza, Ceara, Brazil
来源：
ZYGOTE | 2013年 / 21卷 / 03期
关键词：
Angiogenesis; Folliculogenesis; In vitro culture; Maturation; Tyrosine kinase; FOLLICULAR DEVELOPMENT; CORPUS-LUTEUM; IN-VITRO; PERMEABILITY FACTOR; ANGIOGENIC FACTORS; TYROSINE KINASE; MENSTRUAL-CYCLE; ESTROUS-CYCLE; MICROVASCULAR PERMEABILITY; LYMPHATIC ENDOTHELIUM;
D O I：
10.1017/S0967199411000578
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Ovarian folliculogenesis in mammals is a complex process. Several compounds have been tested during in vitro culture of follicular cells for a better understanding of the mechanisms and factors related to ovarian folliculogenesis in mammals. From these compounds, vascular endothelial growth factor (VEGF) can be highlighted, as it is strongly associated with angiogenesis and, in recent years, its presence in ovarian cells has been investigated extensively. Previous studies have shown that the presence of VEGF protein, as well as mRNA expression of its receptor 2 (VEGFR-2) increases during follicular development. Therefore, it is likely that the interaction between VEGF and VEGFR-2 is crucial to promote follicular development. However, few studies on the influence of this factor on follicular development have been reported. This review addresses aspects related to the structural characterization and mechanism of action of VEGF and its receptors, and their biological importance in the ovary of mammals.
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收藏
页码：295 / 304
页数：10
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