Current Status of Neoadjuvant Endocrine Therapy in Early Stage Breast Cancer

被引：25

作者：

Reinert, Tomas ^{[1
,2
]}

Goncalves, Rodrigo ^{[3
]}

Ellis, Matthew J. ^{[4
]}

机构：

[1] Hosp Canc Mae Deus, Porto Alegre, RS, Brazil

[2] Fed Univ Rio Grande Sul UFRGS, Postgrad Dept Med Sci, Porto Alegre, RS, Brazil

[3] Univ Sao Paulo, Hosp Clin, Dept Obstet & Ginecol, Disciplina Ginecol,Fac Med,Setor Mastol, Sao Paulo, Brazil

[4] Baylor Coll Med, Lester & Sue Smith Breast Canc Ctr, Houston, TX 77030 USA

来源：

CURRENT TREATMENT OPTIONS IN ONCOLOGY | 2018年 / 19卷 / 05期

关键词：

Breast cancer; Endocrine therapy Neoadjuvant; Aromatase inhibitors; Breast-conserving surgery; PHASE-II TRIAL; RANDOMIZED-TRIAL; POSTMENOPAUSAL WOMEN; DOUBLE-BLIND; PREOPERATIVE TREATMENT; PROLIFERATION INDEX; OVARIAN SUPPRESSION; PROGNOSTIC VALUE; KI67; EXPRESSION; ELDERLY WOMEN;

D O I：

10.1007/s11864-018-0538-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Neoadjuvant endocrine therapy (NET) with Ki67-based response monitoring is a practical, cost-effective approach to the management of clinical stage II and III estrogen receptor-positive (ER+) breast cancer. In addition to marked improvements in rates of breast conservation, the identification of extreme responders on the basis of the preoperative endocrine prognostic index (PEPI) provides a rationale to avoid chemotherapy on the basis of highly favorable prognosis in some patients. Finally, samples accrued from patients treated with neoadjuvant therapy are providing valuable insights into the molecular basis for intrinsic resistance to endocrine therapy and promise a more rational basis and precise approach to the systemic treatment of ER+ breast cancer.

引用

页数：14

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