Potential drug-drug interactions between antiretroviral therapy and treatment regimens for multi-drug resistant tuberculosis: Implications for HIV care of MDR-TB co-infected individuals

被引：26

作者：

Mukonzo, Jackson ^{[1
]}

Aklillu, Eleni ^{[2
]}

Marconi, Vincent ^{[3
]}

Schinazi, Raymond F. ^{[4
]}

机构：

[1] Makerere Univ, Dept Pharmacol & Therapeut, Coll Hlth Sci, POB 7072, Kampala, Uganda

[2] Karolinska Univ Hosp Huddinge, Karolinska Inst, Dept Lab Med, Div Clin Pharmacol, Stockholm, Sweden

[3] Emory Univ, Sch Med, Div Infect Dis, Atlanta, GA 30322 USA

[4] Emory Univ, Sch Med, Dept Pediat, Lab Biochem Pharmacol,Ctr AIDS Res, Atlanta, GA 30322 USA

来源：

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | 2019年 / 83卷

基金：

瑞典研究理事会;

关键词：

MDR-TB; HIV; Treatment; Drug-drug interactions;

D O I：

10.1016/j.ijid.2019.04.009

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

HIV-positive TB co-infected patients are at increased risk of multidrug-resistant (MDR)-TB compared to HIV-negative patients. Co-treatment of MDR-TB and HIV is common particularly in Sub-Saharan Africa where the co-morbidity is endemic. We discuss potential cellular metabolic pathway-mediated drug-drug interactions and the possible effect on HIV treatment outcomes of commonly prescribed antiretroviral therapy. (C) 2019 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.

引用

页码：98 / 101

页数：4

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