Mixed Candida albicans strain populations in colonized and infected mucosal tissues

被引：25

作者：

Jacobsen, Mette D. ^{[1
]}

Duncan, Amanda D. ^{[1
]}

Bain, Judith ^{[1
]}

Johnson, Elizabeth M. ^{[2
]}

Naglik, Julian R. ^{[3
]}

Shaw, Duncan J. ^{[1
]}

Gow, Neil A. R. ^{[1
]}

Odds, Frank C. ^{[1
]}

机构：

[1] Inst Med Sci, Aberdeen Fungal Grp, Aberdeen AB25 2ZD, Scotland

[2] Mycol Reference Lab, Bristol, Avon, England

[3] Kings Coll London, Inst Dent, Dept Oral Immunol, London WC2R 2LS, England

来源：

FEMS YEAST RESEARCH | 2008年 / 8卷 / 08期

基金：

英国惠康基金;

关键词：

Candida albicans; MLST; strain typing; epidemiology;

D O I：

10.1111/j.1567-1364.2008.00438.x

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Multilocus sequence typing of six Candida albicans colonies from primary isolation plates revealed instances of colony-to-colony microvariation and carriage of two strain types in single oropharyngeal and vaginal samples. Higher rates of colony variation in commensal samples suggest selection of types from mixed populations either in the shift to pathogenicity or the response to antifungal treatment.

引用

页码：1334 / 1338

页数：5

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