Furo[3,2-b]pyridine: a convenient unit for the synthesis of polyheterocycles

被引：27

作者：

Chartoire, Anthony ^{[1
]}

Comoy, Corinne ^{[1
]}

Fort, Yves ^{[1
]}

机构：

[1] Nancy Univ, CNRS, SRSMC, F-54506 Vandoeuvre Les Nancy, France

来源：

TETRAHEDRON | 2008年 / 64卷 / 48期

关键词：

Furo[3,2-b]pyridine; Tandem Sonogashira coupling/heteroannulation; Pd-catalyzed cross-coupling; Polyheterocycles;

D O I：

10.1016/j.tet.2008.09.008

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and rapid synthesis of furo[3,2-b]pyridine 1 is described using a one-pot Sonogashira coupling/heteroannulation sequence. Regioselective lithiation of this synthon was performed leading to various 2-substituted furo[3,2-b]pyridines. Some of them were used as substrates for short functional synthesis of polyheterocycles. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：10867 / 10873

页数：7

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