Expanded Double Negative T Cells in Patients with Systemic Lupus Erythematosus Produce IL-17 and Infiltrate the Kidneys

被引：603

作者：

Crispin, Jose C. ^{[1
]}

Oukka, Mohamed ^{[2
]}

Bayliss, George ^{[1
]}

Cohen, Robert A. ^{[1
]}

Van Beek, Christine A. ^{[3
]}

Stillman, Isaac E. ^{[3
]}

Kyttaris, Vasileios C. ^{[1
]}

Juang, Yuang-Taung ^{[1
]}

Tsokos, George C. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Cambridge, MA 02139 USA

[3] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Pathol, Boston, MA 02115 USA

来源：

JOURNAL OF IMMUNOLOGY | 2008年 / 181卷 / 12期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.4049/jimmunol.181.12.8761

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Double negative (DN) T cells are expanded in patients with systemic lupus erythematosus (SLE) and stimulate autoantibody production as efficiently as CD4(+) T cells. In this study, we demonstrate that DN T cells from patients with SLE produce significant amounts of IL-17 and IFN-gamma, and expand when stimulated in vitro with an anti-CD3 Ab in the presence of accessory cells. Furthermore, IL-17(+) and DN T cells are found in kidney biopsies of patients with lupus nephritis. Our findings establish that DN T cells produce the inflammatory cytokines IL-17 and IFN-gamma, and suggest that they contribute to the pathogenesis of kidney damage in patients with SLE. The Journal of Immunology, 2008, 181: 8761-8766.

引用

页码：8761 / 8766

页数：6

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