Increased levels of circulating IL-10 in persons recovered from hepatitis C virus (HCV) infection compared with persons with active HCV infection

被引:2
作者
Owusu, Dorcas Ohui [1 ]
Phillips, Richard [2 ]
Owusu, Michael [3 ]
Sarfo, Fred Stephen [4 ]
Frempong, Margaret [5 ]
机构
[1] Garden City Univ Coll GCUC, Dept Med Lab Technol, POB 12775, Kumasi, Ghana
[2] Kwame Nkrumah Univ Sci & Technol KNUST, KNUST, Kumasi Ctr Collaborat Res Trop Med KCCR, Kumasi, Ghana
[3] Kwame Nkrumah Univ Sci & Technol KNUST, Dept Med Diagnost, Univ PO, Kumasi, Ghana
[4] Kwame Nkrumah Univ Sci & Technol, Komfo Anokye Teaching Hosp, Dept Med, Univ PO, Kumasi, Ghana
[5] Kwame Nkrumah Univ Sci & Technol, Dept Mol Med, Kumasi, Ghana
关键词
Hepatitis C virus; Cytokine; Spontaneous recovery; SPONTANEOUS CLEARANCE; HEPATOCELLULAR-CARCINOMA; B-VIRUS; GLOBAL EPIDEMIOLOGY; TRANSMISSION; PREDICTORS; THERAPY; ALCOHOL; ALPHA; PREVALENCE;
D O I
10.1186/s13104-020-05313-w
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
ObjectiveApproximately 70% of all hepatitis C (HCV) infections develop chronic disease. Active or exacerbated chronic hepatitis C infection subsequently progress to liver disease. The role of T-cells secretions in achieving viral clearance is still not well understood. Thus, the current study was set to determine the relationship between the T cell cytokine profiles, biochemical parameters and persistent HCV infection or spontaneous recovery.ResultsTwenty-five percent (41/163) of the anti-HCV positive participants had recovered from HCV and had significantly higher concentration of IL-10 compared to those with active HCV infection (P<0.012). Other circulating cytokines measured; IL-2, IFN gamma, TNF alpha, IL-5 and IL-17 were similar in both groups. Participants with active HCV infection had significantly higher aspartate transaminase (AST) (35 units) and alanine transaminase (46 units) compared to those in the recovered state (P<0.001). Thus, serum levels of IL10 could be explored in larger prospective cohort study as a predictive marker of recovering from an active HCV infection.
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