Aortic dose constraints when reirradiating thoracic tumors

Background and purpose: Improved radiation delivery and planning has allowed, in some instances, for the retreatment of thoracic tumors. We investigated the dose limits of the aorta wherein grade 5 aortic toxicity was observed after reirradiation of lung tumors. Material and methods: In a retrospective analysis, 35 patients were identified, between 1993 and 2008, who received two rounds of external beam irradiation that included the aorta in the radiation fields of both the initial and retreatment plans. We determined the maximum cumulative dose to 1 cm(3) of the aorta (the composite dose) for each patient, normalized these doses to 1.8 Gy/fraction, and corrected them for long-term tissue recovery between treatments (NIDR). Results: The median time interval between treatments was 30 months (range, 1-185 months). The median follow-up of patients alive at analysis was 42 months (range, 14-70 months). Two of the 35 patients (6%) were identified as having grade 5 aortic toxicities. There was a 25% rate of grade 5 aortic toxicity for patients receiving composite doses >= 120.0 Gy (vs. 0% for patients receiving <120.0 Gy) (P = 0.047). Conclusions: Grade 5 aortic toxicities were observed with composite doses >= 120.0 Gy (NIDR >= 90.0 Gy) to 1 cm(3) of the aorta. (C) 2013 Elsevier Ireland Ltd. All rights reserved.