Micellization of poly(L-alanine)/poly( ethylene glycol) block copolymer

被引：0
|
作者：
Zhang, GL
Ma, JB [1 ]
Wang, YN
机构：
[1] Liaoning Univ, Sch Chem Sci & Engn, Shenyang 110036, Peoples R China
[2] Nankai Univ, State Key Lab Funct Polymer Mat Adsorpt & Separat, Inst Polymer Chem, Tianjin 300071, Peoples R China
来源：
CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE | 2006年 / 27卷 / 04期
关键词：
poly ( amino acid); block copolymer; ring-opening polymerization; alpha-Helical structure; micellization; critical micelle concentration;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Block copolymers of poly (L-alanine)/poly(ethylene glycol) (PAME) were synthesized by ning opening polymerization and their structures were characterized. The secondary structure was investigated by circular dichroism(CD). The micellization and critical micelle concentrations(CMC) of PAME in water were monitored by fluorescent probe technique. The diameter and distribution of micelles were characterized by DLS and its shape was observed by TEM. The results show that the poly(amino acid) segment of block copolymer chains existed as a-helical conformation in aqueous solution. The block copolymers of PAME-1 and PAME-2 could form spherical micelles at room temperature, whose diameter was about several hundred nanometer. The CMC of PAME-1 micelle was 1.99 x 10(-5) mol/L, which depends on the PLA content of the copolymers.
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页码：767 / 770
页数：4
相关论文
共 12 条
  • [1] Novel amphiphilic block copolymers by polymer reactions and their use for solubilization of metal salts and metal colloids
    Antonietti, M
    Forster, S
    Hartmann, J
    Oestreich, S
    [J]. MACROMOLECULES, 1996, 29 (11) : 3800 - 3806
  • [2] GRES R, 1994, SCIENCE J, V263, P1600
  • [3] HOLTZWARTH G, 1965, J AM CHEM SOC, V87, P218
  • [4] Doxorubicin-loaded poly(ethylene glycol)-poly(β-benzyl-l-aspartate) copolymer micelles:: their pharmaceutical characteristics and biological significance
    Kataoka, K
    Matsumoto, T
    Yokoyama, M
    Okano, T
    Sakurai, Y
    Fukushima, S
    Okamoto, K
    Kwon, GS
    [J]. JOURNAL OF CONTROLLED RELEASE, 2000, 64 (1-3) : 143 - 153
  • [5] Interpolymer hydrogen-bonding complexation induced micellization from polystyrene-b-poly(methyl methacrylate) and PS(OH) in toluene
    Liu, SY
    Zhu, H
    Zhao, HY
    Jiang, M
    Wu, C
    [J]. LANGMUIR, 2000, 16 (08) : 3712 - 3717
  • [6] NEW, EASILY REMOVABLE POLY(ETHYLENE GLYCOL) SUPPORTS FOR THE LIQUID-PHASE METHOD OF PEPTIDE-SYNTHESIS
    PILLAI, VNR
    MUTTER, M
    BAYER, E
    GATFIELD, I
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 1980, 45 (26): : 5364 - 5370
  • [7] Biodegradable polymeric nanoparticles as drug delivery devices
    Soppimath, KS
    Aminabhavi, TM
    Kulkarni, AR
    Rudzinski, WE
    [J]. JOURNAL OF CONTROLLED RELEASE, 2001, 70 (1-2) : 1 - 20
  • [8] WILLIAM H, 1988, TETRAHEDRON LETT J, V29, P4859
  • [9] Wu GL, 2003, CHEM J CHINESE U, V24, P1515
  • [10] Zhang GL, 2001, CHEM J CHINESE U, V22, P227
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