共 51 条
[51]
YARKONY GM, 1986, ARCH PHYS MED REHAB, V67, P834
Evaluation of cardiovascular disease risk in individuals with chronic spinal cord injury
被引：14
作者：
Dorton, Matthew C.
[1
,2
]
Lucci, V-E M.
[1
,2
]
de Groot, Sonja
[3
,4
,5
]
Loughin, Thomas M.
[6
]
Cragg, Jacquelyn J.
[2
,7
]
Kramer, John K.
[2
]
Post, Marcel W. M.
[8
,9
,10
]
Claydon, Victoria E.
[1
,2
]
机构：
[1] Simon Fraser Univ, Dept Biomed Physiol & Kinesiol, Burnaby, BC, Canada
[2] Univ British Columbia, Int Collaborat Repair & Discoveries ICORD, Vancouver, BC, Canada
[3] Reade, Amsterdam Rehabil Res Ctr, Amsterdam, Netherlands
[4] Univ Groningen, Univ Med Ctr Groningen, Ctr Human Movement Sci, Groningen, Netherlands
[5] Vrije Univ Amsterdam, Fac Behav & Movement Sci, Dept Human Movement Sci, Amsterdam, Netherlands
[6] Simon Fraser Univ, Dept Stat & Actuarial Sci, Burnaby, BC, Canada
[7] Univ British Columbia, Fac Pharmaceut Sci, Collaborat Outcomes Res & Evaluat CORE, Vancouver, BC, Canada
[8] Univ Med Ctr Utrecht, Ctr Excellence Rehabil Med, UMC Utrecht Brain Ctr, Utrecht, Netherlands
[9] Hoogstr Rehabil, Utrecht, Netherlands
[10] Univ Groningen, Univ Med Ctr Groningen, Ctr Rehabil, Dept Rehabil Med, Groningen, Netherlands
来源：
关键词：
WAIST CIRCUMFERENCE;
METABOLIC SYNDROME;
PHYSICAL-ACTIVITY;
BODY-COMPOSITION;
ASSOCIATION;
PREVALENCE;
REHABILITATION;
DYSFUNCTION;
SECONDARY;
OBESITY;
D O I：
10.1038/s41393-020-00566-5
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Study design Multicentre, cross-sectional study. Objectives To identify which markers of obesity, injury characteristics and autonomic function variables are related to cardiovascular disease (CVD) risk after spinal cord injury (SCI), and establish cut-points for detection and risk management. Setting Eight SCI rehabilitation centres in the Netherlands. Methods Individuals (n = 257) with a traumatic, chronic (>= 10 years) SCI, with age at injury between 18 and 35 years, completed a self-report questionnaire and a one-day visit to a rehabilitation centre for testing. Three anthropometric measures were tested: body mass index (BMI); waist circumference (WC); and waist-to-height ratio (WHtR). Injury characteristics included: American Spinal Injury Association impairment scale (AIS); duration of injury (DOI); and neurological level of injury (LOI). Cardiovascular autonomic function was assessed from peak heart rate during maximal exercise (HRpeak). Systolic arterial pressure (SAP) and aerobic capacity (VO2peak) were also determined. CVD risk was calculated using the Framingham risk score (FRS). Results All anthropometric variables were associated with FRS, with WC showing the strongest correlation (r = 0.41,p < 0.001) and greatest area under the curve (0.73) for 10-year CVD risk (%). WC, DOI, SAP, HRpeak, LOI, and VO2peak(variable importance: 0.81, 1.0, 0.98, 0.98, 0.66, 0.68, respectively) were important predictive variables for 10-year CVD risk in individuals with SCI. Conclusions We confirm that WC is a simple, practical measure of CVD risk, and along with DOI and markers of cardiovascular autonomic function, plays a role in the increased CVD risk following SCI.
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页码：716 / 729
页数：14
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