Origin of Contractile Force during Cell Division of Bacteria

被引:47
作者
Ghosh, Biplab [1 ,2 ]
Sain, Anirban [1 ]
机构
[1] Indian Inst Technol, Dept Phys, Bombay 400076, Maharashtra, India
[2] Bhabha Atom Res Ctr, Div Theoret Phys, Bombay 400085, Maharashtra, India
关键词
D O I
10.1103/PhysRevLett.101.178101
中图分类号
O4 [物理学];
学科分类号
0702 ;
摘要
When a bacterium divides, its cell wall at the division site grows radially inward like the shutter of a camera and guillotines the cell into two halves. The wall is pulled upon from inside by a polymeric ring, which itself shrinks in radius. The ring is made of an intracellular protein FtsZ (filamenting temperature sensitive Z) and thus is called the Z ring. It is not understood how the Z ring generates the required contractile force. We propose a theoretical model and simulate it to show how the natural curvature of the FtsZ filaments and lateral attraction among them may facilitate force generation.
引用
收藏
页数:4
相关论文
共 24 条
[1]   Molecular model of the contractile ring [J].
Biron, D ;
Alvarez-Lacalle, E ;
Tlusty, T ;
Moses, E .
PHYSICAL REVIEW LETTERS, 2005, 95 (09)
[2]   GTP-DEPENDENT POLYMERIZATION OF ESCHERICHIA-COLI FTSZ PROTEIN TO FORM TUBULES [J].
BRAMHILL, D ;
THOMPSON, CM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (13) :5813-5817
[3]   ELECTRON-MICROSCOPE STUDY OF SEPTUM FORMATION IN ESCHERICHIA-COLI STRAIN-B AND STRAIN-B-R DURING SYNCHRONOUS GROWTH [J].
BURDETT, IDJ ;
MURRAY, RGE .
JOURNAL OF BACTERIOLOGY, 1974, 119 (03) :1039-1056
[4]   THE ESSENTIAL BACTERIAL CELL-DIVISION PROTEIN FTSZ IS A GTPASE [J].
DEBOER, P ;
CROSSLEY, R ;
ROTHFIELD, L .
NATURE, 1992, 359 (6392) :254-256
[5]  
*EPAPS, EPRLTAO101068843 EPA
[6]   Bacterial cell division protein FtsZ assembles into protofilament sheets and minirings, structural homologs of tubulin polymers [J].
Erickson, HP ;
Taylor, DW ;
Taylor, KA ;
Bramhill, D .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (01) :519-523
[7]   NONLINEAR DYNAMICS OF STIFF POLYMERS [J].
GOLDSTEIN, RE ;
LANGER, SA .
PHYSICAL REVIEW LETTERS, 1995, 75 (06) :1094-1097
[8]   Essential cell division protein FtsZ assembles into one monomer-thick ribbons under conditions resembling the crowded intracellular environment [J].
González, JM ;
Jiménez, M ;
Vélez, M ;
Mingorance, J ;
Andreu, JM ;
Vicente, M ;
Rivas, G .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (39) :37664-37671
[9]   Cooperative behavior of Escherichia coli cell-division protein FtsZ assembly involves the preferential cyclization of long single-stranded fibrils [J].
González, JM ;
Vélez, M ;
Jiménez, M ;
Alfonso, C ;
Schuck, P ;
Mingorance, J ;
Vicente, M ;
Minton, AP ;
Rivas, G .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (06) :1895-1900
[10]   Langevin computer simulations of bacterial protein filaments and the force-generating mechanism during cell division [J].
Horger, I. ;
Velasco, E. ;
Mingorance, J. ;
Rivas, G. ;
Tarazona, P. ;
Velez, M. .
PHYSICAL REVIEW E, 2008, 77 (01)