Herpes simplex virus type 2 infection as a biomarker for sexual debut among young people in sub-Saharan Africa: a literature review

被引：13
作者：
Bastien, S. [1 ]
Mason-Jones, A. J. [2 ,3 ]
De Koker, P. [3 ,4 ]
Mmbaga, E. J. [5 ]
Ross, D. A. [6 ]
Mathews, C. [2 ,3 ]
机构：
[1] Univ Oslo, Fac Med, Inst Basic Med Sci, N-0372 Oslo, Norway
[2] Univ Cape Town, Med Res Council, Hlth Syst Res Unit, ZA-7925 Cape Town, South Africa
[3] Univ Cape Town, Adolescent Hlth Res Unit, ZA-7925 Cape Town, South Africa
[4] Univ Ghent, Int Ctr Reprod Hlth, B-9000 Ghent, Belgium
[5] Muhimbili Univ Hlth & Allied Sci, Dept Epidemiol & Biostat, Dar Es Salaam, Tanzania
[6] London Sch Hyg & Trop Med, Dept Infect Dis Epidemiol, MRC Trop Epidemiol Grp, London WC1, England
来源：
INTERNATIONAL JOURNAL OF STD & AIDS | 2012年 / 23卷 / 11期
关键词：
sexually transmitted infections; STI; herpes simplex type 2; HSV-2; seroprevalence; genital herpes; biological marker; sexual debut; Africa; HUMAN-IMMUNODEFICIENCY-VIRUS; PROSTATE-SPECIFIC ANTIGEN; AGE-SPECIFIC PREVALENCE; RISK-FACTORS; TRANSMITTED INFECTIONS; HIV PREVENTION; VAGINAL FLUID; HUMAN-PAPILLOMAVIRUS; GENITAL HERPES; PREGNANT-WOMEN;
D O I：
10.1258/ijsa.2012.011433
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Biological markers are needed in order to provide objective measures to validate self-reported sexual behaviour and interpret prevention trial data. In this review, we evaluated herpes simplex type 2 virus (HSV-2), one of the most prevalent sexually transmitted infections in sub-Saharan Africa as a biological marker of sexual debut. Based on our findings, we do not recommend using HSV-2 as a biomarker for sexual debut due to its low transmission probabilities and the fact that HSV-2 prevalence is not 100% among potential sexual partners. We recommend that the validation of alternative biological measures should be prioritized, and included in future studies and trials of interventions to reduce sexual health risk.
引用
收藏
页码：761 / 766
页数：6
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