Regulation of the UNC-18-Caenorhabditis elegans syntaxin complex by UNC-13

被引：0
|
作者：
Sassa, T
Harada, S
Ogawa, H
Rand, JB
Maruyama, IN
Hosono, R
机构：
[1] Univ Tokushima, Sch Med, Dept Nutr, Tokushima 7700042, Japan
[2] Kanazawa Univ, Fac Med, Ctr Biomed Res & Educ, Kanazawa, Ishikawa 9208640, Japan
[3] Kanazawa Univ, Fac Med, Dept Phys Informat, Kanazawa, Ishikawa 9208640, Japan
[4] Fujita Hlth Univ, Dept Biol, Aichi 4701192, Japan
[5] Oklahoma Med Res Fdn, Program Mol & Cell Biol, Oklahoma City, OK 73104 USA
[6] Scripps Res Inst, Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA
来源：
JOURNAL OF NEUROSCIENCE | 1999年 / 19卷 / 12期
关键词：
UNC-18; Ce syntaxin; UNC-13; SNARE complex; synaptic vesicle; exocytosis;
D O I：
暂无
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The Caenorhabditis elegans unc-13, unc-18, and unc-64 genes are required for normal synaptic transmission. The UNC-18 protein binds to the unc-64 gene product C. elegans syntaxin (Ce syntaxin). However, it is not clear how this protein complex is regulated. We show that UNC-13 transiently interacts with the UNC-18-Ce syntaxin complex, resulting in rapid displacement of UNC-18 from the complex. Genetic and biochemical evidence is presented that UNC-13 contributes to the modulation of the interaction between UNC-18 and Ce syntaxin.
引用
收藏
页码：4772 / 4777
页数：6
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