Aliskiren reduces portal pressure in cirrhotic rats

被引：5

作者：

Chang, Ching-Chih ^{[1
,2
]}

Huang, Hui-Chun ^{[2
,3
]}

Lee, Wen-Shin ^{[1
,2
]}

Wang, Sun-Sang ^{[2
,3
,4
]}

Lee, Fa-Yauh ^{[2
,3
]}

Lin, Han-Chieh ^{[2
,3
]}

Nong, Jing-Yi ^{[3
]}

Lee, Shou-Dong ^{[2
,3
]}

机构：

[1] Taipei Vet Gen Hosp, Dept Med, Div Gen Med, Taipei, Taiwan

[2] Natl Yang Ming Univ, Sch Med, Taipei 112, Taiwan

[3] Taipei Vet Gen Hosp, Dept Med, Div Gastroenterol, Taipei, Taiwan

[4] Taipei Vet Gen Hosp, Dept Med Affair & Planning, Taipei, Taiwan

来源：

LIVER INTERNATIONAL | 2012年 / 32卷 / 04期

关键词：

RENIN INHIBITOR;

D O I：

10.1111/j.1478-3231.2011.02695.x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

引用

页码：692 / 693

页数：2

共 8 条

[1] Angiotensin II induces contraction and proliferation of human hepatic stellate cells [J].

Bataller, R ;

Ginès, P ;

Nicolás, JM ;

Görbig, MN ;

Garcia-Ramallo, E ;

Gasull, X ;

Bosch, J ;

Arroyo, V ;

Rodés, J .

GASTROENTEROLOGY, 2000, 118 (06) :1149-1156

[2] AT1 receptor antagonist Candesartan in selected cirrhotic patients: Effect on portal pressure and liver fibrosis markers [J].

Debernardi-Venon, Wilma ;

Martini, Silvia ;

Blasi, Fiorella ;

Vizio, Barbara ;

Termine, Angela ;

Poli, Giuseppe ;

Brunello, Franco ;

Alessandria, Carlo ;

Bonardi, Renato ;

Saracco, Giorgio ;

Rizzetto, Mario ;

Marzano, Alfredo .

JOURNAL OF HEPATOLOGY, 2007, 46 (06) :1026-1033

[3] Renin inhibitor aliskiren improves impaired nitric oxide Bioavailability and protects against atherosclerotic changes [J].

Imanishi, Toshio ;

Tsujioka, Hiroto ;

Ikejima, Hideyuki ;

Kuroi, Akio ;

Takarada, Shigeho ;

Kitabata, Hironori ;

Tanimoto, Takashi ;

Muragaki, Yasuteru ;

Mochizuki, Seiichi ;

Goto, Masami ;

Yoshida, Kiyoshi ;

Akasaka, Takashi .

HYPERTENSION, 2008, 52 (03) :563-572

[4] Aliskiren, a novel renin inhibitor, is renoprotective in a model of advanced diabetic nephropathy in rats [J].

Kelly, D. J. ;

Zhang, Y. ;

Moe, G. ;

Naik, G. ;

Gilbert, R. E. .

DIABETOLOGIA, 2007, 50 (11) :2398-2404

[5] Chronic liver injury in rats and humans upregulates the novel enzyme angiotensin converting enzyme 2 [J].

Paizis, G ;

Tikellis, C ;

Cooper, ME ;

Schembri, JM ;

Lew, RA ;

Smith, AI ;

Shaw, T ;

Warner, FJ ;

Zuilli, A ;

Burrell, LM ;

Angus, PW .

GUT, 2005, 54 (12) :1790-1796

[6] Hemodynamic effects of the angiotensin II receptor antagonist irbesartan in patients with cirrhosis and portal hypertension [J].

Schepke, M ;

Werner, E ;

Biecker, E ;

Schiedermaier, P ;

Heller, J ;

Neef, M ;

Stoffel-Wagner, B ;

Hofer, U ;

Caselmann, WH ;

Sauerbruch, T .

GASTROENTEROLOGY, 2001, 121 (02) :389-395

[7] Pharmacokinetics, safety, and tolerability of the oral renin inhibitor aliskiren in patients with hepatic impairment [J].

Vaidyanathan, Sujato ;

Warren, Vance ;

Yeh, ChingMing ;

Bizot, Marie-Noelle ;

Dieterich, Hans Armin ;

Dole, William R. .

JOURNAL OF CLINICAL PHARMACOLOGY, 2007, 47 (02) :192-200

[8] Renin inhibitors, clinical experience [J].

Westermann, Dirk ;

Schmieder, Roland ;

Schultheiss, Heinz-Peter ;

Tschoepe, Carsten .

JOURNAL OF MOLECULAR MEDICINE-JMM, 2008, 86 (06) :691-695

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