Association between the findings of metachronous secondary primary malignancies and the number of Lugol-voiding lesions

被引：9

作者：

Katada, Chikatoshi ^{[1
]}

Yokoyama, Tetsuji ^{[2
]}

Yano, Tomonori ^{[3
]}

Oda, Ichiro ^{[4
]}

Shimizu, Yuichi ^{[5
]}

Takemura, Kenichi ^{[6
]}

Koike, Tomoyuki ^{[7
]}

Takizawa, Kohei ^{[8
]}

Hirao, Motohiro ^{[9
]}

Okada, Hiroyuki ^{[10
]}

Nakayama, Norisuke ^{[11
]}

Kubota, Yutaro ^{[12
]}

Matsuo, Yasumasa ^{[13
]}

Kawakubo, Hirofumi ^{[14
]}

Ishikawa, Hideki ^{[15
]}

Yokoyama, Akira ^{[16
]}

Muto, Manabu ^{[17
]}

机构：

[1] Kitasato Univ, Sch Med, Dept Gastroenterol, Sagamihara, Kanagawa, Japan

[2] Natl Inst Publ Hlth, Dept Hlth Promot, Wako, Saitama, Japan

[3] Natl Canc Ctr Hosp East, Dept Gastroenterol & Endoscopy, Kashiwa, Chiba, Japan

[4] Natl Canc Ctr, Endoscopy Div, Tokyo, Japan

[5] Hokkaido Univ, Grad Sch Med, Dept Gastroenterol, Sapporo, Hokkaido, Japan

[6] Ishikawa Prefectural Cent Hosp, Dept Gastroenterol, Kanazawa, Ishikawa, Japan

[7] Tohoku Univ, Grad Sch Med, Div Gastroenterol, Sendai, Miyagi, Japan

[8] Shizuoka Canc Ctr, Div Endoscopy, Shizuoka, Japan

[9] Natl Hosp Org, Osaka Natl Hosp, Dept Surg, Osaka, Japan

[10] Okayama Univ, Dept Gastroenterol & Hepatol, Grad Sch Med Dent & Pharmaceut Sci, Okayama, Japan

[11] Kanagawa Canc Ctr, Dept Gastroenterol, Yokohama, Kanagawa, Japan

[12] Showa Univ, Dept Med, Sch Med, Div Gastroenterol, Tokyo, Japan

[13] St Marianna Univ, Sch Med, Dept Internal Med, Div Gastroenterol & Hepatol, Kawasaki, Kanagawa, Japan

[14] Kawasaki Municipal Kawasaki Hosp, Dept Endoscopy Ctr, Kawasaki, Kanagawa, Japan

[15] Kyoto Prefectural Univ Med, Dept Mol Targeting Canc Prevent, Kyoto, Japan

[16] Natl Hosp Org Kurihama Med & Addict Ctr, Clin Res Unit, Yokosuka, Kanagawa, Japan

[17] Kyoto Univ Hosp, Dept Clin Oncol, Kyoto, Japan

来源：

DISEASES OF THE ESOPHAGUS | 2020年 / 33卷 / 09期

关键词：

endoscopic resection; esophageal cancer; Lugol-voiding lesions; metachronous cancer; secondary primary malignancy; SQUAMOUS-CELL CARCINOMA; ALDEHYDE DEHYDROGENASE GENOTYPES; 2ND PRIMARY-CANCER; POOLED ANALYSIS; ESOPHAGEAL CANCER; NECK-CANCER; INTERNATIONAL HEAD; DNA-ADDUCTS; RISK; ALCOHOL;

D O I：

10.1093/dote/doz110

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

This study was designed to evaluate the relation between dysplastic squamous epithelium in the esophageal mucosa and the development of metachronous secondary primary malignancies (mSPM) other than esophagus after endoscopic resection (ER) in patients with early esophageal squamous cell carcinoma (SCC). We studied 330 patients with early esophageal SCC who underwent ER as a post hoc analysis of a prospective multicenter cohort study (UMIN Clinical Trials Registry ID UMIN000001676). Lugol-voiding lesions (LVL) were graded into 3 categories (A=no lesion; B=1 to 9 lesions; C >= 10 lesions). The following variables were studied: (i) the incidences of mSPM other than esophagus; (ii) the standardized incidence ratios (SIRs) of mSPM; (iii) the cumulative incidence and total number of mSPM other than esophagus; and (iv) predictors of mSPM other than esophagus on analysis with a multivariate Cox proportional-hazards model. After a median follow-up of 46.6 months, mSPM other than esophagus was diagnosed in a total of 73 patients (90 lesions). Among the 106 patients in group C, 37 patients had mSPM (51 lesions), including head and neck cancer in 14 patients (24 lesions) and gastric cancer in 12 patients (16 lesions). The SIR of mSPM was 3.61 in this study subjects. An increase in the LVL grade (A to B to C) was associated with a progressive increase in the cumulative incidence rate of mSPM other than esophagus (P=0.017 for A vs. C, P=0.023 for B vs. C). An increase in the LVL grade (A to B to C) was also associated with a progressive increase in the total number of mSPM other than esophagus per 100 person-years (primary events, relative risk [RR]=1.66 and 3.24 for grades B and C, respectively, vs. A, P=0.002 for trend; all events, RR=1.81 and 4.66 for grades B and C, respectively, vs. A, P<0.0001 for trend). LVL grade C was a strong predictor of mSPM other than esophagus (RR=3.41 for A vs. C). LVL grade may be a useful predictor of the risk of mSPM other than esophagus after ER in patients with early esophageal SCC.

引用

页数：9

共 24 条

[1] DNA adducts from acetaldehyde: implications for alcohol-related carcinogenesis [J].

Brooks, PJ ;

Theruvathu, JA .

ALCOHOL, 2005, 35 (03) :187-193

[2] Risk of second primary cancer among esophageal cancer patients: A pooled analysis of 13 cancer registries [J].

Chuang, Shu-Chun ;

Hashibe, Mia ;

Scelo, Ghislaine ;

Brewster, David H. ;

Pukkala, Eero ;

Friis, Soren ;

Tracey, Elizabeth ;

Weiderpass, Elisabete ;

Hemminki, Kari ;

Tamaro, Sharon ;

Chia, Kee-Seng ;

Pompe-Kim, Vera ;

Kliewer, Erich V. ;

Tonita, Jon M. ;

Martos, Carmen ;

Jonasson, Jon G. ;

Dresler, Carolyn M. ;

Boffetta, Paolo ;

Brennan, Paul .

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2008, 17 (06) :1543-1549

[3] Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer:: Pooled analysis in the international head and neck cancer epidemiology consortium [J].

Hashibe, Mia ;

Brennan, Paul ;

Benhamou, Simone ;

Castellsague, Xavier ;

Chu Chen ;

Paula Curado, Maria ;

Dal Maso, Luigino ;

Dauct, Alexander W. ;

Fabianova, Eleonora ;

Wunsch-Filho, Victor ;

Franceschi, Silvia ;

Hayes, Richard B. ;

Herrero, Rolando ;

Koifman, Sergio ;

La Vecchia, Carlo ;

Lazarus, Philip ;

Levi, Fabio ;

Mates, Dana ;

Matos, Elena ;

Menezes, Ana ;

Muscat, Joshua ;

Eluf-Neto, Jose ;

Olshan, Andrew F. ;

Rudnai, Peter ;

Schwartz, Stephen M. ;

Smith, Elaine ;

Sturgis, Erich M. ;

Szeszenia-Dabrowska, Neonilia ;

Talamini, Renato ;

Wei, Qingyi ;

Winn, Deborah M. ;

Zaridze, David ;

Zatonski, Witold ;

Zhang, Zuo-Feng ;

Berthiller, Julien ;

Boffetta, Paolo .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2007, 99 (10) :777-789

[4] Lugol-Voiding Lesions Are an Important Risk Factor for a Second Primary Squamous Cell Carcinoma in Patients With Esosphageal Cancer or Head and Neck Cancer [J].

Hori, Keisuke ;

Okada, Hiroyuki ;

Kawahara, Yoshiro ;

Takenaka, Ryuta ;

Shimizu, Sachiko ;

Ohno, Yuko ;

Onoda, Tomoo ;

Sirakawa, Yasuhiro ;

Naomoto, Yoshio ;

Yamamoto, Kazuhide .

AMERICAN JOURNAL OF GASTROENTEROLOGY, 2011, 106 (05) :858-866

[5] Factors associated with the presence of multiple Lugol-voiding lesions in patients with esophageal squamous-cell carcinoma [J].

Katada, C. ;

Muto, M. ;

Tanabe, S. ;

Higuchi, K. ;

Sasaki, T. ;

Azuma, M. ;

Ishido, K. ;

Katada, N. ;

Sakuramoto, S. ;

Yamashita, K. ;

Masaki, T. ;

Nakayama, M. ;

Okamoto, M. ;

Koizumi, W. .

DISEASES OF THE ESOPHAGUS, 2014, 27 (05) :457-462

[6] Alcohol Consumption and Multiple Dysplastic Lesions Increase Risk of Squamous Cell Carcinoma in the Esophagus, Head, and Neck [J].

Katada, Chikatoshi ;

Yokoyama, Tetsuji ;

Yano, Tomonori ;

Kaneko, Kazuhiro ;

Oda, Ichiro ;

Shimizu, Yuichi ;

Doyama, Hisashi ;

Koike, Tomoyuki ;

Takizawa, Kohei ;

Hirao, Motohiro ;

Okada, Hiroyuki ;

Yoshii, Takako ;

Konishi, Kazuo ;

Yamanouchi, Takenori ;

Tsuda, Takashi ;

Omori, Tai ;

Kobayashi, Nozomu ;

Shimoda, Tadakazu ;

Ochiai, Atsushi ;

Amanuma, Yusuke ;

Ohashi, Shinya ;

Matsuda, Tomonari ;

Ishikawa, Hideki ;

Yokoyama, Akira ;

Muto, Manabu .

GASTROENTEROLOGY, 2016, 151 (05) :860-+

[7] Risk of superficial squamous cell carcinoma developing in the head and neck region in patients with esophageal squamous cell carcinoma [J].

Katada, Chikatoshi ;

Muto, Manabu ;

Nakayama, Meijin ;

Tanabe, Satoshi ;

Higuchi, Katsuhiko ;

Sasaki, Tohru ;

Azuma, Mizutomo ;

Ishido, Kenji ;

Katada, Natsuya ;

Yamashita, Keishi ;

Nemoto, Masayuki ;

Shibata, Tomotaka ;

Masaki, Takashi ;

Okamoto, Makito ;

Koizumi, Wasaburo .

LARYNGOSCOPE, 2012, 122 (06) :1291-1296

[8] Independent and combined effects of alcohol intake, tobacco smoking and betel quid chewing on the risk of esophageal cancer in Taiwan [J].

Lee, CH ;

Lee, JM ;

Wu, DC ;

Hsu, HK ;

Kao, EL ;

Huang, HL ;

Wang, TN ;

Huang, MC ;

Wu, MT .

INTERNATIONAL JOURNAL OF CANCER, 2005, 113 (03) :475-482

[9] Effects of ALDH2 Genotype, PPI Treatment and L-Cysteine on Carcinogenic Acetaldehyde in Gastric Juice and Saliva after Intragastric Alcohol Administration [J].

Maejima, Ryuhei ;

Iijima, Katsunori ;

Kaihovaara, Pertti ;

Hatta, Waku ;

Koike, Tomoyuki ;

Imatani, Akira ;

Shimosegawa, Tooru ;

Salaspuro, Mikko .

PLOS ONE, 2015, 10 (04)

[10] Risk of second primary malignancy after esophagectomy for squamous cell carcinoma of the thoracic esophagus [J].

Matsubara, T ;

Yamada, K ;

Nakagawa, A .

JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (23) :4336-4341

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