Structural covariance of the neostriatum with regional gray matter volumes

被引：36

作者：

Soriano-Mas, C. ^{[1
,2
]}

Harrison, B. J. ^{[3
,4
]}

Pujol, J. ^{[5
]}

Lopez-Sola, M. ^{[5
]}

Hernandez-Ribas, R. ^{[1
,2
]}

Alonso, P. ^{[1
,2
,6
]}

Contreras-Rodriguez, O. ^{[5
]}

Gimenez, M. ^{[5
]}

Blanco-Hinojo, L. ^{[5
,7
]}

Ortiz, H. ^{[5
]}

Deus, J. ^{[5
,8
]}

Menchon, J. M. ^{[1
,2
,6
]}

Cardoner, N. ^{[1
,2
,6
]}

机构：

[1] Bellvitge Univ Hosp IDIBELL, Dept Psychiat, Barcelona 08907, Spain

[2] Ctr Invest Biomed Red Salud Mental CIBERSAM, Carlos III Hlth Inst, Madrid, Spain

[3] Univ Melbourne, Dept Psychiat, Melbourne Neuropsychiat Ctr, Melbourne, Vic, Australia

[4] Melbourne Hlth, Melbourne, Vic, Australia

[5] CRC Hosp del Mar, Barcelona, Spain

[6] Univ Barcelona, Sch Med, Dept Clin Sci, Barcelona, Spain

[7] Fundacio IMIM PRBB, Barcelona, Spain

[8] Autonomous Univ Barcelona, Dept Clin & Hlth Psychol, Barcelona, Spain

来源：

BRAIN STRUCTURE & FUNCTION | 2013年 / 218卷 / 03期

基金：

英国医学研究理事会;

关键词：

Structural covariance; Brain anatomy; Structural plasticity; Brain connectivity; Neostriatum; Neuroimaging; Magnetic resonance imaging; OBSESSIVE-COMPULSIVE DISORDER; SOURCE-BASED MORPHOMETRY; HUMAN BRAIN-DEVELOPMENT; FRONTAL CORTICAL AREAS; BASAL GANGLIA; FUNCTIONAL CONNECTIVITY; CORTICOSTRIATAL CIRCUITS; CORTEX; SCHIZOPHRENIA; NETWORKS;

D O I：

10.1007/s00429-012-0422-5

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

The caudate and putamen nuclei have been traditionally divided into dorsal and ventral territories based on their segregated patterns of functional and anatomical connectivity with distributed cortical regions. Activity-dependent structural plasticity may potentially lead to the development of regional volume correlations, or structural covariance, between the different components of each cortico-striatal circuit. Here, we studied the whole-brain structural covariance patterns of four neostriatal regions belonging to distinct cortico-striatal circuits. We also assessed the potential modulating influence of laterality, age and gender. T1-weighted three-dimensional magnetic resonance images were obtained from ninety healthy participants (50 females). Following data pre-processing, the mean signal value per hemisphere was calculated for the 'seed' regions of interest, located in the dorsal and ventral caudate and the dorsal-caudal and ventral-rostral putamen. Statistical parametric mapping was used to estimate whole-brain voxel-wise structural covariance patterns for each striatal region, controlling for the shared anatomical variance between regions in order to obtain maximally specific structural covariance patterns. As predicted, segregated covariance patterns were observed. Age was found to be a relevant modulator of the covariance patterns of the right caudate regions, while laterality effects were observed for the dorsal-caudal putamen. Gender effects were only observed via an interaction with age. The different patterns of structural covariance are discussed in detail, as well as their similarities with the functional and anatomical connectivity patterns reported for the same striatal regions in other studies. Finally, the potential mechanisms underpinning the phenomenon of volume correlations between distant cortico-striatal structures are also discussed.

引用

页码：697 / 709

页数：13

共 71 条

[1] PARALLEL ORGANIZATION OF FUNCTIONALLY SEGREGATED CIRCUITS LINKING BASAL GANGLIA AND CORTEX [J].