Amino acid based bioanalogous polymers. Novel regular poly(ester urethane)s and poly(ester urea)s based on bis(L-phenylalanine) alpha,omega-alkylene diesters

被引：40

作者：

Kartvelishvili, T ^{[1
]}

Tsitlanadze, G ^{[1
]}

Edilashvili, L ^{[1
]}

Japaridze, N ^{[1
]}

Katsarava, R ^{[1
]}

机构：

[1] GEORGIAN ACAD SCI, INST MOL BIOL & BIOPHYS, GE-380079 TBILISI, GEORGIA

来源：

MACROMOLECULAR CHEMISTRY AND PHYSICS | 1997年 / 198卷 / 06期

关键词：

D O I：

10.1002/macp.1997.021980620

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Novel biodegradable regular poly(ester urethane)s 2 (eta(red) less than or equal to 0,62 dL/g) were synthesized for the first time by polycondensation of di-p-toluenesulfonic acid salts of bis(phenylalanine) alpha,omega-alkylene diesters 1 with di-p-nitrophenyl trimethylenedicarbonate (4) under mild conditions in organic solvents in the presence of triethylamine as acid acceptor. The first synthesis of homopoly(ester urea)s 3 (eta(red) less than or equal to 0,33 dL/g) was carried out by polycondensation of 1 with di-p-nitrophenyl carbonate (5) under the same conditions. Preliminary in vitro evaluation of specific and nonspecific hydrolysis of the polymers obtained has been brought about using potentiometric titration.

引用

页码：1921 / 1932

页数：12

共 32 条

[1]

[Anonymous], PROG POLYM SCI

[2] HETEROCHAIN POLYMERS BASED ON NATURAL AMINO-ACIDS - SYNTHESIS AND ENZYMATIC-HYDROLYSIS OF REGULAR POLY(ESTER AMIDE)S BASED ON BIS(L-PHENYLALANINE) ALPHA,OMEGA-ALKYLENE DIESTERS AND ADIPIC ACID [J].

ARABULI, N ;

TSITLANADZE, G ;

EDILASHVILI, L ;

KHARADZE, D ;

GOGUADZE, T ;

BERIDZE, V ;

GOMURASHVILI, Z ;

KATSARAVA, R .

MACROMOLECULAR CHEMISTRY AND PHYSICS, 1994, 195 (06) :2279-2289

[3] NOVEL POLYAMIDES FROM L-CYSTINE [J].

BECHAOUCH, S ;

COUTIN, B ;

SEKIGUCHI, H .

MACROMOLECULAR RAPID COMMUNICATIONS, 1994, 15 (02) :125-131

[4]

BERIDZE V, UNPUB

[5] SYNTHESIS AND CHARACTERIZATION OF A POLYTARTARAMIDE BASED ON L-LYSINE [J].

BOU, JJ ;

MUNOZGUERRA, S .

POLYMER, 1995, 36 (01) :181-186

[6]

BOUSTA M, 1990, MECH KINETICS POLYM, P121

[7]

BRUIN P, 1988, MAKROMOL CHEM-RAPID, V9, P589

[8] BIODEGRADABLE POLYMERS FOR BIOMEDICAL USES [J].

HAYASHI, T .

PROGRESS IN POLYMER SCIENCE, 1994, 19 (04) :663-702

[9]

HUANG SJ, 1979, J APPL POLYM SCI, V23, P429, DOI 10.1002/app.1979.070230212

[10] Amino acid based bioanalogous polymers. Synthesis of novel poly(urethane amide)s based on N,N'-(trimethylenedioxydicarbonyl)bis(phenylalanine) [J].

Kartvelishvili, T ;

Kvintradze, A ;

Katsarava, R .

MACROMOLECULAR CHEMISTRY AND PHYSICS, 1996, 197 (01) :249-257

← 1 2 3 4 →