Modeling BCMA-Specific Regulated CAR T Cells to Target Long-Lived Plasma Cells or Multiple Myeloma

被引:0
|
作者
Jacobs, Chester [1 ,2 ]
Honaker, Yuchi [1 ,2 ]
Leung, Wai-Hang [3 ]
Stoffers, Claire [1 ,2 ]
Cheng, Rene [1 ,2 ]
English, Jeb [1 ,2 ]
Sommer, Karen [1 ,2 ]
Khan, Iram [1 ,2 ]
James, Richard [1 ,2 ,4 ,5 ]
Astrakhan, Alexander [3 ]
Rawlings, David J. [1 ,2 ,4 ,5 ]
机构
[1] Seattle Childrens Res Inst, Ctr Immun & Immunotherapies, Seattle, WA USA
[2] Seattle Childrens Res Inst, Program Cell & Gene Therapy, Seattle, WA USA
[3] Bluebird Bio Inc, Cambridge, MA USA
[4] Univ Washington, Sch Med, Dept Pediat, Seattle, WA 98195 USA
[5] Univ Washington, Sch Med, Dept Immunol, Seattle, WA USA
关键词
D O I
暂无
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
366
引用
收藏
页码:173 / 174
页数:2
相关论文
共 50 条
  • [11] Gamma secretase inhibition increases recognition of multiple myeloma by BCMA-specific chimeric antigen receptor modified T cells
    Hill, Tyler
    Pont, Margot
    Abbott, Joe
    Kelliher, Jessica
    Salter, Alexander
    Liu, Steven
    Green, Damian
    Riddell, Stanley
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2017, 5
  • [12] The BCMA:Tomato Mouse - a new reporter to characterize long-lived plasma cells
    Schulz, Sebastian R.
    Wittner, Jens
    Kueh, Andrew J.
    Pal, Martin
    Herold, Marko J.
    Schuh, Wolfgang
    Jaeck, Hans-Martin
    JOURNAL OF IMMUNOLOGY, 2020, 204 (01):
  • [13] Long-lived plasma cells in the spleen
    Bohannon, Caitlin
    Joshy, Jacob
    JOURNAL OF IMMUNOLOGY, 2013, 190
  • [14] Novel CS1 CAR-T Cells and Bispecific CS1-BCMA CAR-T Cells Effectively Target Multiple Myeloma
    Golubovskaya, Vita
    Zhou, Hua
    Li, Feng
    Berahovich, Robert
    Sun, Jinying
    Valentine, Michael
    Xu, Shirley
    Harto, Hizkia
    Sienkiewicz, John
    Huang, Yanwei
    Wu, Lijun
    BIOMEDICINES, 2021, 9 (10)
  • [15] Preclinical Evaluation of Allogeneic CAR T Cells Targeting BCMA for the Treatment of Multiple Myeloma
    Sommer, Cesar
    Boldajipour, Bijan
    Kuo, Tracy C.
    Bentley, Trevor
    Sutton, Janette
    Chen, Amy
    Geng, Tao
    Dong, Holly
    Galetto, Roman
    Valton, Julien
    Pertel, Thomas
    Juillerat, Alexandre
    Gariboldi, Annabelle
    Pascua, Edward
    Brown, Colleen
    Chin, Sherman M.
    Sai, Tao
    Ni, Yajin
    Duchateau, Philippe
    Smith, Julianne
    Rajpal, Arvind
    Van Blarcom, Thomas
    Chaparro-Riggers, Javier
    Sasu, Barbra J.
    MOLECULAR THERAPY, 2019, 27 (06) : 1126 - 1138
  • [17] Efficacy and safety of BCMA-specific CAR T cell-based therapy in relapsed/refractory multiple myeloma patients with extramedullary disease
    Qi, Yue Kun
    Li, Zhenyu
    Xu, Kailin
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2023, 23 : S57 - S57
  • [18] Strategies to target long-lived plasma cells for treating hemophilia A inhibitors
    Liu, Chao Lien
    Lyle, Meghan J.
    Shin, Simon C.
    Miao, Carol H.
    CELLULAR IMMUNOLOGY, 2016, 301 : 65 - 73
  • [19] Memory B Cells and Long-lived Plasma Cells
    Ionescu, Lavinia
    Urschel, Simon
    TRANSPLANTATION, 2019, 103 (05) : 890 - 898
  • [20] Homozygous BCMA gene deletion in response to anti-BCMA CAR T cells in a patient with multiple myeloma
    Matteo C. Da Vià
    Oliver Dietrich
    Marietta Truger
    Panagiota Arampatzi
    Johannes Duell
    Anke Heidemeier
    Xiang Zhou
    Sophia Danhof
    Sabrina Kraus
    Manik Chatterjee
    Manja Meggendorfer
    Sven Twardziok
    Maria-Elisabeth Goebeler
    Max S. Topp
    Michael Hudecek
    Sabrina Prommersberger
    Kristen Hege
    Shari Kaiser
    Viktoria Fuhr
    Niels Weinhold
    Andreas Rosenwald
    Florian Erhard
    Claudia Haferlach
    Hermann Einsele
    K. Martin Kortüm
    Antoine-Emmanuel Saliba
    Leo Rasche
    Nature Medicine, 2021, 27 : 616 - 619