Modeling BCMA-Specific Regulated CAR T Cells to Target Long-Lived Plasma Cells or Multiple Myeloma

被引：0
|
作者：
Jacobs, Chester [1 ,2 ]
Honaker, Yuchi [1 ,2 ]
Leung, Wai-Hang [3 ]
Stoffers, Claire [1 ,2 ]
Cheng, Rene [1 ,2 ]
English, Jeb [1 ,2 ]
Sommer, Karen [1 ,2 ]
Khan, Iram [1 ,2 ]
James, Richard [1 ,2 ,4 ,5 ]
Astrakhan, Alexander [3 ]
Rawlings, David J. [1 ,2 ,4 ,5 ]
机构：
[1] Seattle Childrens Res Inst, Ctr Immun & Immunotherapies, Seattle, WA USA
[2] Seattle Childrens Res Inst, Program Cell & Gene Therapy, Seattle, WA USA
[3] Bluebird Bio Inc, Cambridge, MA USA
[4] Univ Washington, Sch Med, Dept Pediat, Seattle, WA 98195 USA
[5] Univ Washington, Sch Med, Dept Immunol, Seattle, WA USA
来源：
MOLECULAR THERAPY | 2019年 / 27卷 / 04期
关键词：
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
366
引用
收藏
页码：173 / 174
页数：2
相关论文
共 50 条
  • [1] BCMA-SPECIFIC TAC RECEPTOR-ENGINEERED T CELLS FOR MULTIPLE MYELOMA
    Bezverbnaya, K.
    Lau, V.
    Aarts, C.
    Denisova, G.
    Afsahi, A.
    Cummings, D.
    Helsen, C. W.
    Bramson, J.
    CYTOTHERAPY, 2018, 20 (05) : S9 - S9
  • [2] Waking up exhausted BCMA-specific T cells in myeloma
    Sacco, Antonio
    Roccaro, Aldo M.
    BLOOD, 2020, 143 (10) : 840 - 841
  • [3] Preclinical evaluation of BCMA-specific TAC receptor-engineered T cells for multiple myeloma
    Bezverbnaya, Ksenia
    Aarts, Craig
    Helsen, Christopher
    Denisova, Galina
    Afsahi, Arya
    Evelegh, Carole
    Cummings, Derek
    Bramson, Jonathan
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2017, 5
  • [4] γ-Secretase inhibition increases efficacy of BCMA-specific chimeric antigen receptor T cells in multiple myeloma
    Pont, Margot J.
    Hill, Tyler
    Cole, Gabriel O.
    Abbott, Joe J.
    Kelliher, Jessica
    Salter, Alexander I.
    Hudecek, Michael
    Comstock, Melissa L.
    Rajan, Anusha
    Patel, Bharvin K. R.
    Voutsinas, Jenna M.
    Wu, Qian
    Liu, Lingfeng
    Cowan, Andrew J.
    Wood, Brent L.
    Green, Damian J.
    Riddell, Stanley R.
    BLOOD, 2019, 134 (19) : 1585 - 1597
  • [5] Durable remissions with BCMA-specific chimeric antigen receptor (CAR)-modified T cells in patients with refractory/relapsed multiple myeloma.
    Fan, Frank
    Zhao, Wanhong
    Liu, Jie
    He, Aili
    Chen, Yinxia
    Cao, Xingmei
    Yang, Nan
    Wang, Baiyan
    Zhang, Pengyu
    Zhang, Yilin
    Wang, Fangxia
    Lei, Bo
    Gu, Liufang
    Wang, Xugeng
    Zhuang, Qiuchuan
    Zhang, Wanggang
    JOURNAL OF CLINICAL ONCOLOGY, 2017, 35 (18)
  • [6] Targeting Multiple Myeloma through the Biology of Long-Lived Plasma Cells
    Utley, Adam
    Lipchick, Brittany
    Lee, Kelvin P.
    Nikiforov, Mikhail A.
    CANCERS, 2020, 12 (08) : 1 - 17
  • [7] Durable remissions with BCMA-specific chimeric antigen receptor (CAR)-modified T cells in patients with refractory/relapsed multiple myeloma.
    Fan, Frank
    Zhao, Wanhong
    Liu, Jie
    He, Aili
    Chen, Yinxia
    Cao, Xingmei
    Yang, Nan
    Wang, Baiyan
    Zhang, Pengyu
    Zhang, Yilin
    Wang, Fangxia
    Lei, Bo
    Gu, Liufang
    Wang, Xugeng
    Zhuang, Qiuchuan
    Zhang, Wanggang
    JOURNAL OF CLINICAL ONCOLOGY, 2017, 35
  • [8] A Novel Bcma-Specific, Centyrin-Based CAR-T Product for the Treatment of Multiple Myeloma
    Hermanson, David L.
    Barnett, Burton Earle
    Rengarajan, Srinivas
    Codde, Rebecca
    Wang, Xinxin
    Tan, Yening
    Martin, Christopher E.
    Smith, Jenessa Barbara
    He, Jin
    Mathur, Rohit
    Yan, Jing
    Neelapu, Sattva S.
    Osertag, Eric M.
    Shedlock, Devon J.
    BLOOD, 2016, 128 (22)
  • [9] Differentiation of BCMA-specific induced pluripotent stem cells into rejuvenated CD8αβ+ T cells targeting multiple myeloma
    Bae, Jooeun
    Kitayama, Shuichi
    Herbert, Zach
    Daheron, Laurence
    Kurata, Keiji
    Keskin, Derin B.
    Livak, Kenneth
    Li, Shuqiang
    Tarannum, Mubin
    Romee, Rizwan
    Samur, Mehmet
    Munshi, Nikhil C.
    Kaneko, Shin
    Ritz, Jerome
    Anderson, Kenneth C.
    BLOOD, 2024, 143 (10) : 895 - 911
  • [10] BCMA is essential for the survival of long-lived bone marrow plasma cells
    O'Connor, BP
    Raman, VS
    Erickson, LD
    Cook, WJ
    Weaver, LK
    Ahonen, C
    Lin, LL
    Mantchev, GT
    Bram, RJ
    Noelle, RJ
    JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 199 (01): : 91 - 97
12345