The OSCAR-IB Consensus Criteria for Retinal OCT Quality Assessment

被引:474
作者
Tewarie, Prejaas [1 ]
Balk, Lisanne [1 ]
Costello, Fiona [2 ,3 ]
Green, Ari [4 ]
Martin, Roland [5 ]
Schippling, Sven [5 ]
Petzold, Axel [6 ]
机构
[1] Vrije Univ Amsterdam, Med Ctr, MS Ctr Amsterdam, Amsterdam, Netherlands
[2] Univ Calgary, Dept Clin Neurosci, Calgary, AB, Canada
[3] Univ Calgary, Dept Surg, Calgary, AB, Canada
[4] Univ Calif San Francisco, Dept Neurol, Multiple Sclerosis Ctr, San Francisco, CA USA
[5] Univ Med Ctr Hamburg Eppendorf, Inst Neuroimmunol & Clin Multiple Sclerosis Res I, Hamburg, Germany
[6] UCL Inst Neurol, London, England
关键词
OPTICAL COHERENCE TOMOGRAPHY; FIBER LAYER THICKNESS; MULTIPLE-SCLEROSIS;
D O I
10.1371/journal.pone.0034823
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Background: Retinal optical coherence tomography (OCT) is an imaging biomarker for neurodegeneration in multiple sclerosis (MS). In order to become validated as an outcome measure in multicenter studies, reliable quality control (QC) criteria with high inter-rater agreement are required. Methods/Principal Findings: A prospective multicentre study on developing consensus QC criteria for retinal OCT in MS: (1) a literature review on OCT QC criteria; (2) application of these QC criteria to a training set of 101 retinal OCT scans from patients with MS; (3) kappa statistics for inter-rater agreement; (4) identification reasons for inter-rater disagreement; (5) development of new consensus QC criteria; (6) testing of the new QC criteria on the training set and (7) prospective validation on a new set of 159 OCT scans from patients with MS. The inter-rater agreement for acceptable scans among OCT readers (n = 3) was moderate (kappa 0.45) based on the non-validated QC criteria which were entirely based on the ophthalmological literature. A new set of QC criteria was developed based on recognition of: (O) obvious problems, (S) poor signal strength, (C) centration of scan, (A) algorithm failure, (R) retinal pathology other than MS related, (I) illumination and (B) beam placement. Adhering to these OSCAR-IB QC criteria increased the inter-rater agreement to kappa from moderate to substantial (0.61 training set and 0.61 prospective validation). Conclusions: This study presents the first validated consensus QC criteria for retinal OCT reading in MS. The high inter-rater agreement suggests the OSCAR-IB QC criteria to be considered in the context of multicentre studies and trials in MS.
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