Radioiodine therapy accelerates apoptosis in peripheral blood lymphocytes of patients with differentiated thyroid cancer

被引：7

作者：

Vrndic, O. ^{[1
]}

Milosevic-Djordjevic, O. ^{[1
,2
]}

Djurdjevic, P. ^{[1
,3
]}

Jovanovic, D. ^{[1
,3
]}

Mijatovic, L. ^{[1
,3
]}

Jeftic, I. ^{[1
]}

Simonovic, S. Zivancevic ^{[1
]}

机构：

[1] Univ Kragujevac, Fac Med Sci, Kragujevac, Serbia

[2] Univ Kragujevac, Fac Sci, Kragujevac, Serbia

[3] Clin Ctr Kragujevac, Kragujevac, Serbia

来源：

NEOPLASMA | 2013年 / 60卷 / 05期

关键词：

apoptosis; differentiated thyroid cancer; micronuclei; peripheral blood lymphocytes; radioactive iodine; RADIATION-INDUCED APOPTOSIS; MICRONUCLEI FREQUENCY; CHROMOSOMAL-ABERRATIONS; MOLECULAR-MECHANISMS; T-LYMPHOCYTES; CELLS; RADIOSENSITIVITY; EXPOSURE; FOCI;

D O I：

10.4149/neo_2013_074

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Both apoptosis and micronuclei formation reflect cytogenetic damage in cells and could contribute to cell homeostasis. The aim of this study was to evaluate apoptosis in peripheral blood lymphocytes (PBLs)of patients with differentiated thyroid cancer (DTC) before and after 131-iodine (131-I)-therapy and its correlation with micronuclei (MN) frequency. The study population included 18 DTC patients and 18 healthy donors. Apoptotic cells were detected using the Annexin V-FITC/7-AAD kit and MN frequency by cytokinesis-block MN assay. The difference between early apoptosis in PBLs of DTC patients before therapy and controls (9.88 +/- 4.99% vs. 6.64 +/- 2.07%, p = 0.003) was significant, as well as between early apoptosis in PBLs of DTC patients before and after 131-I-therapy (9.88 +/- 4.99% vs. 13.53 +/- 6.57%, p = 0.008). The MN frequency and early apoptosis in PBLs of DTC patients was positively correlated before (r = 0.540, p = 0.021) and after 131-I-therapy (r = 0.585, p = 0.014). Thyroid cancer patients had a significantly increased early apoptosis in PBLs, which further increased after 131-I-therapy in association with MN frequency.

引用

页码：568 / 575

页数：8

共 52 条

[1] Formation of micronuclei and of clastogenic factor(s) in patients receiving therapeutic doses of iodine-131 [J].