Paradoxical effect of SARS-CoV-2 infection in patients with immune thrombocytopenia

被引：16
|
作者：
de la Cruz-Benito, Beatriz [1 ]
Rivas-Pollmar, Maria I. [1 ]
Alvarez Roman, Maria T. [1 ]
Trelles-Martinez, Roberto [1 ]
Martin-Salces, Monica [1 ]
Lazaro-del Campo, Paula [1 ]
Ramirez-Lopez, Andres [1 ]
Garcia-Barcenilla, Sara [1 ]
Cebanu, Tamara [1 ]
Acuna-Butta, Paula [1 ]
Monzon-Manzano, Elena [1 ]
Gonzalez-Zorrilla, Elena [1 ]
Jimenez-Yuste, Victor [1 ,2 ]
Butta, Nora V. [1 ]
机构：
[1] La Paz Univ Hosp IdiPAZ, Unit Thrombosis & Hemostasis, Dept Hematol, Madrid, Spain
[2] Univ Autonoma Madrid, Madrid, Spain
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 2021年 / 192卷 / 06期
关键词：
immune thrombocytopenia; COVID-19; SARS-CoV-2; thrombocytosis; lymphopenia; ACUTE RESPIRATORY SYNDROME;
D O I：
10.1111/bjh.17077
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Thrombocytopenia has been identified as a common complication of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in the general population. In an attempt to determine the impact of coronavirus disease 2019 (COVID-19) in patients with immune thrombocytopenia (ITP), a retrospective single-centre study was performed. Thrombocytosis was observed in patients with chronic ITP after SARS-CoV-2 infection, frequently needing treatment adjustment or even discontinuation of therapy. Relapses and newly diagnosed cases showed a fast response after initial treatment compared to ITP. Reduced immune activity due to lymphopenia during COVID-19 could explain this paradoxical effect, although further studies are needed.
引用
收藏
页码：973 / 977
页数：5
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