Recent Advances in Methylation: A Guide for Selecting Methylation Reagents

被引：199

作者：

Chen, Yantao ^{[1
]}

机构：

[1] AstraZeneca Gothenburg, IMED Biotech Unit, Med Chem Cardiovasc Renal & Metab, Gothenburg, Sweden

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2019年 / 25卷 / 14期

关键词：

dimethylation; medicinal chemistry; methylation; mono N-methylation; N-methyl amino acids; N-methyl peptides; MONO-N-METHYLATION; C-H ALKYLATION; ALPHA-AMINO-ACIDS; NICKEL-CATALYZED METHYLATION; LATE-STAGE FUNCTIONALIZATION; 5-HT2C RECEPTOR AGONISTS; CROSS-COUPLING REACTIONS; SOLID-PHASE SYNTHESIS; DIMETHYL CARBONATE; REDUCTIVE METHYLATION;

D O I：

10.1002/chem.201803642

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Methylation is a well-known structural modification in organic and medicinal chemistry. This review summarizes recent advances in methylation by categorizing specific methylation reagents. The challenges of mono N-methylation of aliphatic amines and N-methylation of peptides are discussed. This review will be useful for chemists wanting to select the appropriate reagents for methylation chemistry. Based on the large diversity of methylation reagents and their wide scope, this review also broadens perspectives on which strategies to select for utilizing a particular methylation, resulting in an increased flexibility in synthetic route planning.

引用

收藏

页码：3405 / 3439

页数：35

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