Probiotic Lactobacillus and Bifidobacterial Lectins Against Candida albicans and Staphylococcus aureus Clinical Strains: New Class of the Pathogen Biofilm Destructors

被引：15

作者：

Lakhtin, M. ^{[1
]}

Alyoshkin, V. ^{[1
]}

Lakhtin, V. ^{[1
]}

Afanasyev, S. ^{[1
]}

Pozhalostina, L. ^{[1
]}

Pospelova, V. ^{[1
]}

机构：

[1] GN Gabrichevsky Res Inst Epidemiol & Microbiol, Moscow, Russia

来源：

PROBIOTICS AND ANTIMICROBIAL PROTEINS | 2010年 / 2卷 / 03期

关键词：

Probiotics; Lectins; Antimicrobials; Synergistic action; Candida albicans; Staphylococcus aureus; Clinical strains; Biofilms; CELL-DENSITY; MOLECULES; RESISTANCE; BACTERIA; HOST;

D O I：

10.1007/s12602-010-9046-3

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Preparations of probiotic bifidobacterial and lactobacillus lectins possessed system affinity to mannan and mucin-type polymers. It was shown that these lectins possess fungistatic and fungicidal activities against nystatin-resistant Candida albicans clinical strains. Lectins revealed destructive properties with respect to C. albicans and Staphylococcus aureus biofilms, depending on clinical strain origin and lectin preparation type. Synergistic antipathogen activities between lectins and between lectins and nystatin were observed. In the presence of lectins, pathogen biofilm degradation occurred in sequential steps, including biofilm refinement, appearance of edge cavities, segmentation, detachment of fragments and their lysis. Fungal response to lectins was more complex compared to that of staphylococci. Cold stress improved pictures of lectin antipathogen action. The data indicate that probiotic bacterial lectins are members of a new class of antimicrobials-destructors of pathogen biofilms.

引用

页码：186 / 196

页数：11

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